GlpBio

FLT3

FLT3(FMS样酪氨酸激酶3)

FLT3 (FMS-like tyrosine kinase 3) is a cytokine receptor which belongs to the receptor tyrosine kinase class III and plays a role in cell survival, proliferation, and differentiation.

FLT3 相关产品(91)

  • GC15556 structure
    GC15556UNC2025
    CAS: 1429881-91-3
    纯度: >99.50%

    An orally bioavailable inhibitor of Mer and Flt3

  • GC15739 structure
    GC15739CHIR-124
    CAS: 405168-58-3
    纯度: >98.00%

    A selective Chk1 inhibitor

  • GC16499 structure
    GC16499Sorafenib Tosylate
    CAS: 475207-59-1
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC16519 structure
    GC16519ENMD-2076
    CAS: 934353-76-1
    纯度: >98.00%

    A multi-kinase inhibitor

  • GC16604 structure
    GC16604Altiratinib
    CAS: 1345847-93-9
    纯度: >98.00%

    A multiple kinase inhibitor

  • GC17369 structure
    GC17369Sorafenib
    CAS: 284461-73-0
    纯度: >99.50% / >99.00%

    索拉非尼Sorafenib是Raf-1和B-Raf的多激酶抑制剂，IC50分别为6 nM和22 nM;Sorafenib对VEGFR-2 VEGFR-3 PDGFR-β Flt-3和c-KIT也有抑制作用，IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM;索拉非尼能诱导自噬细胞凋亡和激活铁死亡，并具有抗肿瘤活性。

  • GC17615 structure
    GC17615Quizartinib (AC220)
    CAS: 950769-58-1
    纯度: >98.50%

    Quizartinib (AC220)是一种高效的第二代Fms样酪氨酸激酶3（FLT3）抑制剂，对FLT3-ITD和FLT3-WT的IC 50 值分别为1.1nM和4.2nM。

  • GC17959 structure
    GC17959AZD2932
    CAS: 883986-34-3
    纯度: >98.00%

    A multi-kinase inhibitor

  • GC18167 structure
    GC18167AC710
    CAS: 1351522-04-7
    纯度: >99.50%

    A PDGFR family kinase inhibitor

  • GC19080 structure
    GC19080BPR1J-097
    CAS: 1327167-19-0

    An FLT3 inhibitor

  • GC19092 structure
    GC19092CCT241736
    CAS: 1402709-93-6
    纯度: >98.00%

    A dual inhibitor of Aurora kinases and FLT3

  • GC19158 structure
    GC19158FLT3-IN-2
    CAS: 923562-23-6
    纯度: >99.00%

    An inhibitor of FLT3, c-Kit, and c-FMS

  • GC19332 structure
    GC19332Sitravatinib
    CAS: 1123837-84-2
    纯度: >99.50%

    Sitravatinib是一种酪氨酸激酶抑制剂（TKI），能够作用于TYRO3、AX和MERTK（TAM）受体、血管内皮生长因子受体（VEGFR）家族、c-Kit 和 c-MET。

  • GC19482 structure
    GC19482Gilteritinib
    CAS: 1254053-43-4
    纯度: >99.00%

    Gilteritinib（ASP2215，Xospata）用于复发和/或难治性 AML (R/R AML)。

  • GC19772 structure
    GC19772FLT3-IN-3
    CAS: 2229050-90-0
    纯度: >99.50%

    An FLT3 inhibitor

  • GC32769 structure
    GC32769MRX-2843 (UNC2371)
    CAS: 1429882-07-4
    纯度: >98.00%

    A Mer and FLT3 inhibitor

  • GC32968 structure
    GC32968FLT3-IN-1
    CAS: 1472797-69-5

    FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.

  • GC32995 structure
    GC32995JNJ-47117096 hydrochloride (MELK-T1 hydrochloride)
    CAS: 1610536-69-0
    纯度: >98.00%

    JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) 是有效的选择性 MELK 抑制剂，IC50 为 23 nM，也有效抑制 Flt3，IC50 为 18 nM。

  • GC33049 structure
    GC33049FN-1501
    CAS: 1429515-59-2
    纯度: >98.00%

    FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively.

  • GC33064 structure
    GC33064CG-806 (Luxeptinib)
    CAS: 1616428-23-9
    纯度: >99.00%

    CG-806 (Luxeptinib) (CG-806) 是一种具有口服活性、可逆、一流、非共价且有效的 pan-FLT3/pan-BTK 抑制剂。 CG-806 (Luxeptinib) 在急性髓性白血病细胞中诱导细胞周期停滞、凋亡或自噬。

  • GC33141 structure
    GC33141SKLB4771 (FLT3-IN-1)
    CAS: 1370256-78-2
    纯度: >98.00%

    SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10?nM.

  • GC33242 structure
    GC33242FLT3-IN-1 Succinate
    CAS: 1702864-11-6

    FLT3-IN-1Succinate是有效地FLT3抑制剂，来自专利WO2015056683A1，化合物实例A。

  • GC33362 structure
    GC33362Amuvatinib hydrochloride (MP470 hydrochloride)
    CAS: 1055986-67-8

    A multi-targeted RTK inhibitor

  • GC35315 structure
    GC35315AMG 925 HCl
    CAS: 1401034-19-2
    纯度: >98.00%

    A dual inhibitor of FLT3 and Cdk4