GlpBio

c-MET

c-MET(间质表皮转化因子)

c-MET, also called MET, is a membrane receptor that is essential for embryonic development and wound healing.

c-MET 相关产品(92)

  • GC15779 structure
    GC15779Cabozantinib (XL184, BMS-907351)
    CAS: 849217-68-1
    纯度: >99.50%

    Cabozantinib (XL184,BMS-907351) 是一种新型 MET 和 VEGFR2 抑制剂，可同时抑制转移、血管生成和肿瘤生长。

  • GC16337 structure
    GC16337MK-2461
    CAS: 917879-39-1
    纯度: >99.50%

    A c-MET inhibitor

  • GC16391 structure
    GC16391Amuvatinib (MP-470, HPK 56)
    CAS: 850879-09-3
    纯度: >98.00%

    A multi-targeted RTK inhibitor

  • GC16604 structure
    GC16604Altiratinib
    CAS: 1345847-93-9
    纯度: >98.00%

    A multiple kinase inhibitor

  • GC17772 structure
    GC17772BMS-817378
    CAS: 1174161-69-3

    Potent ATP competitive inhibitor of Met/VEGFR2

  • GC18211 structure
    GC18211Ningetinib
    CAS: 1394820-69-9
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC19102 structure
    GC19102CEP-40783
    CAS: 1437321-24-8
    纯度: >99.00%

    A multi-kinase inhibitor

  • GC19108 structure
    GC19108SCR-1481B1
    CAS: 1174161-86-4
    纯度: >99.50%

    A pyridone

  • GC19140 structure
    GC19140X-376
    CAS: 1365267-27-1
    纯度: >98.00%

    An ALK inhibitor

  • GC19166 structure
    GC19166Glesatinib hydrochloride
    CAS: 1123838-51-6
    纯度: >98.00%

    Glesatinib hydrochloride (MGCD265 hydrochloride) 是一种具有口服活性的强效 MET/SMO 双重抑制剂。 Glesatinib hydrochloride 是一种酪氨酸激酶抑制剂，可拮抗 P-糖蛋白 (P-gp) 介导的非小细胞肺癌 (NSCLC) 中的多药耐药 (MDR)。

  • GC19317 structure
    GC19317S49076
    CAS: 1265965-22-7
    纯度: >99.50%

    S49076 是一种新型、有效的 MET、AXL/MER 和 FGFR1/2/3 抑制剂，IC50 值低于 20 nM。

  • GC19321 structure
    GC19321Savolitinib
    CAS: 1313725-88-0
    纯度: >99.50%

    An inhibitor of c-Met

  • GC30768 structure
    GC30768Dihexa (PNB-0408)
    CAS: 1401708-83-5
    纯度: >98.00%

    Dihexa (PNB-0408)（N-己酸-Tyr-Ile-(6)-氨基己酰胺）是一种具有口服活性、可透过血脑屏障的血管紧张素 IV 类似物。

  • GC32864 structure
    GC32864Ensartinib hydrochloride (X-396 hydrochloride)
    CAS: 2137030-98-7
    纯度: >99.00%

    An ALK inhibitor

  • GC33173 structure
    GC33173TAS-115
    CAS: 1190836-34-0

    A multi-kinase inhibitor

  • GC33189 structure
    GC33189SAR125844
    CAS: 1116743-46-4
    纯度: >98.00%

    SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).

  • GC33190 structure
    GC33190Ensartinib (X-396)
    CAS: 1370651-20-9

    An ALK inhibitor

  • GC33203 structure
    GC33203c-Met-IN-2
    CAS: 1635406-73-3

    c-Met-IN-2是一种有效的，选择性的，可口服的c-Met抑制剂，IC50值为0.6nM，具有抗肿瘤活性。

  • GC33266 structure
    GC33266JNJ-38877618
    CAS: 943540-74-7
    纯度: >98.00%

    JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).

  • GC33273 structure
    GC33273TAS-115 mesylate (TAS-115 methanesulfonate)
    CAS: 1688673-09-7
    纯度: >99.00%

    A multi-kinase inhibitor

  • GC33362 structure
    GC33362Amuvatinib hydrochloride (MP470 hydrochloride)
    CAS: 1055986-67-8

    A multi-targeted RTK inhibitor

  • GC34811 structure
    GC34811SRI 31215 TFA
    CAS: 1832686-44-8
    纯度: >98.50%

    SRI31215(TFA)是一种matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为0.69μM、0.65μM、0.3μM，SRI31215通过阻断pro-HGF的活化，从而模拟了HAI-1/2的活性。

  • GC35095 structure
    GC350952-Phospho-L-ascorbic acid trisodium salt
    CAS: 66170-10-3
    纯度: >97.00% / >99.00%

    Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.

  • GC35716 structure
    GC35716c-Met inhibitor 1
    CAS: 1357072-61-7
    纯度: >98.00%

    c-Met inhibitor 1是c-Met信号通路抑制剂，可作用于胃癌，胰腺癌和恶性胶质瘤。