GlpBio

Mitochondrial Metabolism

Mitochondrial Metabolism(线粒体代谢)

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Mitochondrial Metabolism 相关产品(243)

  • GC18992 structure
    GC18992Duclauxin
    CAS: 1732-37-2

    An antitumor agent

  • GC19021 structure
    GC19021Adjudin
    CAS: 252025-52-8
    纯度: >98.00%

    A derivative of lonidamine

  • GC19138 structure
    GC19138CTPI-2
    CAS: 68003-38-3
    纯度: >98.50%

    A mitochondrial citrate transporter inhibitor

  • GC19221 structure
    GC19221Leucomethylene blue Mesylate
    CAS: 1236208-20-0
    纯度: >98.00%

    An inhibitor of tau aggregation

  • GC19528 structure
    GC195281,4-Benzoquinone
    CAS: 106-51-4
    纯度: >99.00%

    A toxic metabolite of benzene

  • GC19926 structure
    GC19926Methyl malonic acid
    CAS: 108-59-8
    纯度: >99.50%

    A dicarboxylic acid and byproduct of propionate catabolism

  • GC19941 structure
    GC19941 DL-Leucic Acid
    CAS: 498-36-2
    纯度: ≥98%
  • GC25337 structure
    GC25337D-Carnitine hydrochloride
    CAS: 10017-44-4

    D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.

  • GC30014 structure
    GC30014Elamipretide (MTP-131)
    CAS: 736992-21-5
    纯度: >98.00%

    Elamipretide (MTP-131) 作为一种水溶性四肽，可以增强细胞 ATP 合成，从而改善电子传输并减少 ROS 的形成。

  • GC30459 structure
    GC30459Senecionine (Senecionan-11,16-dione, 12-hydroxy-)
    CAS: 130-01-8
    纯度: >99.00%

    A pyrrolizidine alkaloid with hepatotoxic properties

  • GC30512 structure
    GC30512Vatiquinone (EPI-743)
    CAS: 1213269-98-7
    纯度: >98.00%

    A metabolite of α-tocotrienol with antioxidant and ferroptosis inhibitory activity

  • GC31123 structure
    GC31123Mitochonic acid 5 (MA-5)
    CAS: 1354707-41-7
    纯度: >99.00%

    An inhibitor of mitochondrial dysfunction

  • GC31432 structure
    GC31432Asp-AMS
    CAS: 828288-98-8

    Asp-AMS是天冬氨酸腺苷酸的一个类似物，是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂，也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。

  • GC31491 structure
    GC31491Speract
    CAS: 76901-59-2

    Speract是一种调节精子活力的海胆蛋肽，也刺激精子线粒体代谢。

  • GC31646 structure
    GC31646NIM811 ((Melle-4)cyclosporin)
    CAS: 143205-42-9
    纯度: >98.50%

    NIM811 ((Melle-4)cyclosporin) ((Melle-4)cyclosporin; SDZ NIM811 ((Melle-4)cyclosporin)) 是一种口服生物可利用的线粒体通透性转换和亲环素双重抑制剂，在体外对丙型肝炎病毒具有有效的活性(丙肝病毒)。

  • GC31682 structure
    GC31682Mito-TEMPO
    CAS: 1334850-99-5
    纯度: >98.00%

    Mito-Tempo 是一种靶向线粒体的抗氧化剂，具有有效的超氧化物清除特性，可将有毒的超氧化物分子转化为过氧化氢或氧气，随后通过过氧化氢酶或谷胱甘肽过氧化物酶解毒为氧气和水 .在体外，Mito-Tempo 通过增强超氧化物歧化酶 (SOD) 活性和 PI3K/AKT/mTOR 磷酸化而具有更强的保护作用。

  • GC32858 structure
    GC32858ER-000444793
    CAS: 792957-74-5
    纯度: >98.00%

    ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM.

  • GC35262 structure
    GC35262Afzelin
    CAS: 482-39-3
    纯度: >98.00%

    A polyphenolic glycoside flavone with diverse biological activities

  • GC36132 structure
    GC36132Genistein 8-c-glucoside
    CAS: 66026-80-0
    纯度: >99.00%

    Genistein 8-c-glucoside (G8CG) 是从 Lupinus luteus L 花中分离的一种天然葡萄糖苷。Genistein 8-c-glucoside 诱导线粒体膜去极化并诱导细胞凋亡 (apoptosis)。

  • GC36619 structure
    GC36619MitoTam bromide, hydrobromide
    CAS: 1634624-73-9

    MitoTam bromide, hydrobromide 他莫昔芬衍生物，它是一种电子传递链 (ETC) 抑制剂，抑制衰老细胞中的线粒体膜电位变化并影响线粒体形态。MitoTam bromide, hydrobromide 是一种有效的抗癌剂，可以抑制乳腺癌细胞中呼吸复合物 (CI- respiration) 和超复合物 (SCs) 的形成。MitoTam bromide, hydrobromide 诱导细胞凋亡 (apoptosis)。

  • GC36620 structure
    GC36620MitoTam iodide, hydriodide
    CAS: 1634624-74-0

    MitoTam iodide, hydriodide 他莫昔芬衍生物，它是一种电子传递链 (ETC) 抑制剂，抑制衰老细胞中的线粒体膜电位变化并影响线粒体形态。MitoTam iodide, hydriodide 是一种有效的抗癌剂。MitoTam iodide, hydriodide 抑制乳腺癌细胞中呼吸复合物 (CI- respiration) 和超复合物 (SCs) 的形成。MitoTam iodide, hydriodide 可以诱导细胞凋亡 (apoptosis)。

  • GC36658 structure
    GC36658MSDC-0602
    CAS: 1133819-87-0
    纯度: >98.50%

    A PPARγ-sparing thiazolidinedione derivative

  • GC38620 structure
    GC38620Dihydrorotenone
    CAS: 6659-45-6
    纯度: >98.00%

    Dihydrorotenone是一种杀虫剂，是线粒体复合物I的不可逆抑制剂，并且能够穿过血脑屏障。

  • GC39411 structure
    GC39411NL-1
    CAS: 188532-26-5
    纯度: >98.00%

    The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.