GlpBio

Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Endogenous Metabolite 相关产品(1712)

  • GC63106 structure
    GC63106NHC-diphosphate triammonium
    纯度: >98.50%

    NHC-triphosphate triammonium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate triammonium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。

  • GC63107 structure
    GC63107NHC-triphosphate tetraammonium
    纯度: >96.00% / >97.00%

    NHC-triphosphate tetraammonium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate tetraammonium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。

  • GC63113 structure
    GC63113N-Methylphenethylamine
    CAS: 589-08-2
    纯度: >98.00%

    N-Methylphenethylamine 一种天然的仲胺类神经调节剂 (neuromodulator)，可在人的尿液或植物中检测到。

  • GC63116 structure
    GC63116Normetanephrine hydrochloride
    CAS: 1011-74-1

    Normetanephrine ((±)-Normetanephrine) hydrochloride 是去甲肾上腺素 (ne) 的 O-甲基化代谢产物。

  • GC63119 structure
    GC63119NT1-O12B
    CAS: 2739805-63-9

    NT1-O12B 是一种内源性化学物质，也是一种神经递质衍生的类脂质体 (NT-lipidoid)，是几种血脑屏障 (BBB) 非渗透性物质增强脑内转运的有效载体。将 NT1-O12B 掺杂到 BBB 非渗透性脂质纳米粒 (LNPs) 中，可以使 LNPs 具有穿过 BBB 的能力。NT 类脂质体不仅有利于 BBB 的跨膜转运，而且可以将其转运到神经细胞中进行功能基因沉默或基因重组。

  • GC63136 structure
    GC63136Palatinose hydrate
    CAS: 343336-76-5
    纯度: >98.00%

    Isomaltulose (Palatinose) hydrate is a disaccharide carbohydrate widely used during exercise to maintain glycaemia and hydration.

  • GC63140 structure
    GC63140Pentane-1,5-diamine dihydrochloride
    CAS: 1476-39-7

    1,5-Diaminopentane (Cadaverine) is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue.

  • GC63152 structure
    GC63152Potassium 2-hydroxy-2-methylsuccinate
    CAS: 1030365-02-6

    Potassium 2-hydroxy-2-methylsuccinate 是一种内源性代谢产物。

  • GC63161 structure
    GC63161Pyrimidine
    CAS: 289-95-2
    纯度: >99.50%

    Pyrimidine 是一种内源性代谢产物。

  • GC63166 structure
    GC63166Raffinose
    CAS: 512-69-6
    纯度: >98.00%

    Raffinose (Melitose, Melitriose) is a complex carbohydrate, a trisaccharide composed of galactose, fructose, and glucose. It can be broken apart into galactose and sucrose via the enzyme alpha-galactosidase.

  • GC63168 structure
    GC63168rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate
    CAS: 5990-63-6

    rel-(2R,3S)-2,3-Dihydroxysuccinic acid (hydrate) 是一种内源性代谢产物。

  • GC63179 structure
    GC63179S-Adenosyl-L-methionine iodide
    CAS: 3493-13-8
    纯度: >80.00%

    S-(5’-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) 是很重要的甲基供体，存在于所有生物体中。

  • GC63183 structure
    GC63183Secaubryenol
    CAS: 925932-08-7

    Secaubryenol 是一类从 Coussarea macrophylla 中分离的 3,4-七环烷三萜。Secaubryenol 在 10 µg/mL 的剂量下不显示任何细胞毒性。

  • GC63233 structure
    GC63233Toltrazuril sulfoxide
    CAS: 69004-15-5

    Toltrazuril sulfoxide 是托曲脲短暂的中间代谢物 (intermediary metabolite)，在体内可代谢为活性的托曲脲砜 (TZR-SO2)。Toltrazuril 是一种抗原生动物 (antiprotozoal agent) 试剂，作用于 Coccidia 球虫寄生虫。

  • GC63235 structure
    GC63235Trans-2-butene-1,4-dicarboxylic acid
    CAS: 4436-74-2
    纯度: >98.50%

    trans-β-Hydromuconic acid (trans-2-Butene-1,4-dicarboxylic Acid, 3-hexenediodicacid, β-Hydromuconic acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders.

  • GC63237 structure
    GC63237trans-3-Indoleacrylic acid
    CAS: 29953-71-7
    纯度: >98.00% / >95.00%

    trans-3-Indoleacrylic acid is a metabolite of tryptophan.

  • GC63275 structure
    GC63275β-Cryptoxanthin
    CAS: 472-70-8
    纯度: >96.50%

    β-Cryptoxanthin ((3R)-β-Cryptoxanthin) 是从萨摩橘中分离的一种含氧类胡萝卜素，也是有效的抗氧化剂。β-Cryptoxanthin 具有抗应激作用。

  • GC63279 structure
    GC63279γ-Glu-Gly TFA

    γ-Glu-Gly 是一种 γ-谷氨酰二肽，是一种人体脂质代谢物。γ-Glu-Gly 与 GABA (γ-氨基丁酸)结构相似，可作为兴奋性氨基酸的拮抗剂。

  • GC63319 structure
    GC63319Ercalcidiol-d3
    CAS: 1217467-39-4
    纯度: >99.00%

    Ercalcidiol-d3 (25-hydroxy Vitamin D2-d3) 是 Ercalcidiol 的氘代物。Ercalcidiol 是维生素 D2 的代谢产物。Ercalcidiol 可用作维生素 D 状态的指标。

  • GC63352 structure
    GC63352Ebaresdax
    CAS: 1334471-39-4
    纯度: >99.50%

    Ebaresdax对SIN-1诱导的过氧亚硝酸盐氧化和过氧亚硝酸盐介导的细胞毒性均有抑制作用，IC50s分别为3.7±0.80和0.13±0.02 uM。

  • GC63467 structure
    GC63467Hydroxypyruvic acid lithium hydrate
    CAS: 209728-15-4

    Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) 是甘氨酸、丝氨酸和苏氨酸代谢的中间产物 (intermediate)。Hydroxypyruvic acid lithium hydrate 是丝氨酸-丙酮酸氨基转移酶和乙醛酸还原酶/羟基丙酮酸还原酶的底物 (substrate)。Hydroxypyruvic acid lithium hydrate 参与了二甲基甘氨酸脱氢酶缺乏症的代谢紊乱途径。

  • GC63481 structure
    GC63481Succinic acid-d6
    CAS: 21668-90-6

    Succinic acid-d6 (Wormwood acid-d6) 是 Succinic acid 的氘代物。Succinic acid 是三羧酸循环的中间产物，也是无氧代谢的发酵产物之一。

  • GC63497 structure
    GC63497Pedalitin
    CAS: 22384-63-0

    Pedalitin 是酪氨酸酶（IC50=0.28 mM）和α-葡萄糖苷酶抑制剂（IC50=0.29 mM）。

  • GC63577 structure
    GC63577Benzamide-15N
    CAS: 31656-62-9

    Benzamide-15N (NSC-3114-15N) 是一种 15N 标记的 Benzamide. Benzamide 可抑制 poly(ADP-ribose) polymerase (PARP).