γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly TFA has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids[1][2][3].
γ-Glu-Gly TFA is a key component that influence the flavor of mature cheese. In S. cerevisiae, γ-Glutamyltransferase (GGT) produces two γ-glutamyl peptides, γ-Glu-Glu and γ-Glu-Gly[1].
[1]. Kit-Yi Leung, et al. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. J Inherit Metab Dis. 2020 Nov;43(6):1186-1198.
[2]. Sonu Yadav, et al. Metabolomics shows the Australian dingo has a unique plasma profile. Sci Rep. 2021 Mar 4;11(1):5245.
[3]. Olga A Sofyanovich, et al. Multiple pathways for the formation of the γ-glutamyl peptides γ-glutamyl-valine and γ- glutamyl-valyl-glycine in Saccharomyces cerevisiae. PLoS One. 2019 May 9;14(5):e0216622.