Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for Endogenous Metabolite

Cat.No. 产品名称 Information
GC12850 2-Deoxy-D-ribose
2-脱氧-D-核糖
A reducing sugar
GC17436 2'-Deoxycytidine-5'-monophosphoric acid
2'-脱氧胞苷-5'-单磷酸
A deoxyribonucleotide
GC17478 2-Deoxycytidine
2'-脱氧胞苷; Deoxycytidine; Cytosine deoxyriboside; Deoxyribose cytidine
A deoxyribonucleoside
GC11642 2-Deoxyadenosine
2'-脱氧腺苷
2-Deoxyadenosine 是一种核苷腺苷衍生物，与双链 DNA 中的脱氧胸苷 (T) 配对。
GC12964 2-3-Dihydroxybenzoic acid
2,3-二羟基苯甲酸; Catecholcarboxylic acid; NSC 27435
2-3-二羟基苯甲酸是一种在血浆中发现的正常人体苯甲酸代谢物，在服用阿司匹林后水平会升高。
GC13877 1,2-Dipalmitoyl-sn-glycerol
1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964
A diacylglycerol
GC16375 (±)-Jasmonic Acid methyl ester
甲基茉莉酮酸酯,(±)-Methyl Jasmonate
(±)-Jasmonic Acid methyl ester是一种重要的天然植物信号分子和植物激素，具备多种生物学活性。
GC11969 Adenosine-5'-diphosphate
二磷酸腺苷,Adenosine Pyrophosphate,ADP,5′-ADP
Adenosine-5'-diphosphate是 P2Y1、P2Y12、P2Y13 等嘌呤能 P2Y 受体的天然激动剂，可直接结合并触发下游信号级联。
GC14433 7α,25-dihydroxy Cholesterol
7Α,25-二羟基胆固醇,7α,25-DHC
A potent and selective agonist of GPR183
GC13887 25(R)-27-hydroxy Cholesterol
27-羟基胆固醇
25(R)-27-hydroxy Cholesterol是肝脏X受体（LXR）α和LXRβ的激动剂，EC₅₀值分别为0.085μM和0.071μM。
GC14511 All-trans Retinal
视黄醛,Retinaldehyde,Vitamin A aldehyde
All-trans Retinal 是一种具有活性的vitamin A aldehyde，对CRBP-I和CRBP-II蛋白的K_d值分别为50nM和90nM。
GC16438 L-Histidinol (hydrochloride)
L-组氨醇二盐酸盐,(S)-Histidinol
An intermediate in L-histidine biosynthesis
GC12829 5-hydroxy Tryptophol
5-羟基色醇
A metabolite of tryptophan
GC14954 L-Canaline
6-硝基-2-氨苯酚-4-磺酸
A natural inhibitor of aminotransferases
GC10663 Dihydrodaidzein
二氢大豆苷元; (±)-Dihydrodaidzein
An active metabolite of daidzein
GC10827 Oxipurinol
羟基嘌呤,Alloxanthine|NSC 76239
An inhibitor of xanthine oxidase and active metabolite of allopurinol
GC15815 Thymidine
胸苷; DThyd; NSC 21548

A pyrimidine nucleoside
GC17287 Iberin
3-甲基亚磺酰丙基异硫氰酸酯,NSC 321801

A natural isothiocyanate
GC10533 7,8-dihydro-L-Biopterin
7,8-二氢生物蝶呤
A precursor in the synthesis of BH₄
GC15993 Lauric Acid
月桂酸
A medium-chain fatty acid
GC10042 Vitamin E
天然维生素E
脂溶性维生素
GC10396 S-Adenosylhomocysteine
S-(5'-腺苷)-L-高半胱氨酸,SAH (S-Adenosylhomocysteine); AdoHcy

S-腺苷同型半胱氨酸 (SAH) （S-Adenosylhomocysteine）是一种氨基酸衍生物，是蛋氨酸代谢中的关键中间代谢产物。
GC12713 5-Aminovaleric acid hydrochloride
5-氨基戊酸
5-氨基戊酸盐酸盐被认为是 γ-氨基丁酸 (GABA) 的亚甲基同系物，并作为弱 GABA 激动剂发挥作用。
GC11222 Methylthioadenosine
5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine
Methylthioadenosine是多胺生物合成过程中由 S-腺苷甲硫氨酸(SAMe)产生的含硫腺嘌呤核苷。Methylthioadenosine常用于结肠炎、肝病和各种癌症疾病的研究。
GC15161 Calcium D-Panthotenate
泛酸钙; Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt
D-泛酸钙（维生素B5钙盐）是一种维生素，可以降低苹果汁中棒曲霉素的含量。
GC13955 Enoxolone
甘草次酸
An anti-inflammatory and immunomodulatory compound
GC12395 (D)-(+)-Neopterin
新蝶呤,D-(+)-Neopterin; D-erythro-Neopterin
A biochemical tool to screen for immune disorders
GC16103 Oleylethanolamide
油酰单乙醇胺,N-Oleoylethanolamide; Oleamide MEA; Oleic acid monoethanolamide
An endogenous, potent agonist for PPARα
GC17777 Palmitoylethanolamide
十六酰胺乙醇,Palmidrol; Loramine P 256
An endogenous cannabinoid
GC14042 Oleamide
油酸酰胺
An amide of oleic acid and agonist of CB₁ receptors
GC18105 Enterostatin
人肠抑素
A pentapeptide involved in the regulation of food intake
GC11236 [Leu5]-Enkephalin
亮氨酸脑啡肽,Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin
[Leu5]-Enkephalin是一种通过与阿片受体结合以调节疼痛感知和情绪的内源性δ阿片受体激动剂。
GC12664 Urea
尿素; Carbamide; Carbonyldiamide

尿素是一种强大的蛋白质变性剂，通过直接和间接机制。
GC12203 L-Glutathione Reduced
还原型谷胱甘肽; GSH; γ-L-Glutamyl-L-cysteinyl-glycine

Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases
GC13670 Methylmalonate
甲基丙二酸; Methylpropanedioic acid; Methylmalonate
A dicarboxylic acid and byproduct of propionate catabolism
GC13228 Phosphocreatine disodium salt
磷酸肌酸钠,Disodium creatine phosphate
Phosphocreatine disodium salt是肌肉和大脑等高能量波动需求组织中的重要能量储备物质。
GC11459 Xanthurenic acid
4,8-二羟基喹啉-2-甲酸
Xanthurenic acid是一种内源性II组代谢型谷氨酸受体激动剂，参与丘脑的感觉传递。
GC12327 Corticosterone
皮质酮; 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
Corticosterone (17 deoxycortisol) 是一种具有口服活性的糖皮质激素，由肾上腺皮质产生，对调节边缘系统（包括海马、前额叶皮层和杏仁核）的神经元功能具有重要作用。
GC14203 Citric acid
柠檬酸
柠檬酸是一种天然防腐剂和食品酸味增强剂。
GC17470 (-)-Cotinine
可替宁; (-)-Cotinine; (S)-Cotinine; NIH-10498
A major metabolite of nicotine
GC11195 Sarcosine
肌氨酸; N-Methylglycine; Sarcosin
An intermediate in the biosynthesis of glycine
GC15975 α-Estradiol
α-雌二醇; Alfatradiol; Epiestradiol; Epiestrol
A weak estrogen with neuroprotective effects
GC15948 Prostaglandin E2
前列腺素 E2; PGE2; Dinoprostone
Prostaglandin E2是花生四烯酸在环氧合酶(COX)催化下产生的主要代谢物。
GC15649 Substance P
P物质; Neurokinin P
Substance P作为一种重要的神经肽类神经递质，能够刺激磷脂酰肌醇代谢，EC₅₀值为0.36nM。
GC11064 Spermine tetrahydrochloride
精胺四盐酸盐
A natural polyamine
GC16831 Agmatine sulfate
胍基丁胺；硫酸胍基丁胺；硫酸鲱精胺；胍基丁胺硫酸盐
A polyamine metabolite
GC17591 D-erythro-Sphingosine (synthetic)
鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。
GC13890 (±)-Palmitoylcarnitine chloride
C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine
A long-chain acylcarnitine with intracellular and extracellular roles
GC14301 Spaglumic acid
异冬谷酸,N-Acetylaspartylglutamic acid
A peptide neurotransmitter
GC10123 O-Phospho-L-serine
L-O-磷酸丝氨酸,L-Serine O-phosphate; L-SOP
A glutamate receptor agonist