GlpBio

Drug Metabolite

Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Drug Metabolite 相关产品(498)

  • GC60419 structure
    GC60419(S)-O-Desmethyl Venlafaxine N-Oxide
    CAS: 1021934-03-1

    (S)-O-DesmethylVenlafaxineN-Oxide是(S)-O-DesmethylVenlafaxine的N-氧化物。O-DesmethylVenlafaxine是Venlafaxine的活性代谢产物。Venlafaxine是5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)类的抗抑郁剂。

  • GC60427 structure
    GC60427(Z)-10-Hydroxynortriptyline
    CAS: 47132-19-4
    纯度: >99.00%

    An active metabolite of amitriptyline and nortriptyline

  • GC60474 structure
    GC604742-Hydroxy atorvastatin lactone
    CAS: 163217-74-1

    2-Hydroxyatorvastatinlactone是Atorvastatin的代谢产物。2-Hydroxyatorvastatinlactone是一种口服活性HMG-CoA还原酶抑制剂，具有有效降低血脂的能力。

  • GC60500 structure
    GC605003'-Hydroxy Repaglinide D5
    CAS: 1352792-15-4
    纯度: >98.00%

    3'-HydroxyRepaglinideD5是3'-HydroxyRepaglinide的氘代物。3'-HydroxyRepaglinide是Repaglinide的主要CYP2C8代谢产物。

  • GC60517 structure
    GC605174-Hydroxyatomoxetine
    CAS: 435293-66-6

    A metabolite of atomoxetine

  • GC60523 structure
    GC605234-Methylamino antipyrine hydrochloride
    CAS: 856307-27-2

    An active metabolite of metamizole

  • GC60541 structure
    GC605418-Demethyl Ivabradine
    CAS: 304464-97-9

    8-DemethylIvabradine是Ivabradine的一个代谢物。Ivabradine是具有口服活性的，超极化激活的环核苷酸门控离子通道(HCN)通道阻滞剂。

  • GC60591 structure
    GC60591Apovincaminic acid hydrochloride salt
    CAS: 72296-47-0
    纯度: >98.00%

    Apovincaminicacidhydrochloridesalt是Vinpocetine(VP)的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminicacidhydrochloridesalt具有神经保护作用。

  • GC60831 structure
    GC60831Ezetimibe phenoxy glucuronide
    CAS: 190448-57-8
    纯度: >99.00%

    Ezetimibephenoxyglucuronide(Ezetimibeglucuronide)是Ezetimibe的活性代谢物，具有抗高脂蛋白血症效果。Ezetimibe是有效的胆固醇吸收抑制剂。

  • GC60833 structure
    GC60833FB23
    CAS: 2243736-35-6
    纯度: >99.00%

    FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.

  • GC60920 structure
    GC60920Hydroxyhexamide
    CAS: 3168-01-2
    纯度: >99.50%

    Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.

  • GC61037 structure
    GC61037Mebeverine acid
    CAS: 475203-77-1

    A metabolite of mebeverine

  • GC61115 structure
    GC61115N-Desethyl Oxybutynin D5 hydrochloride
    CAS: 1173018-49-9

    N-DesethylOxybutyninD5hydrochloride是N-DesethylOxybutyninhydrochloride的氘代物。N-DesethylOxybutynin是Oxybutynin的活性代谢产物。Oxybutynin是一种抗胆碱能药，抑制电压依赖型K+通道。

  • GC61137 structure
    GC61137Nordoxepin D3 hydrochloride
    CAS: 1331665-54-3
    纯度: >99.00%

    NordoxepinD3hydrochloride(DesmethyldoxepinD3hydrochloride)是Nordoxepinhydrochloride的氘代物。Nordoxepinhydrochloride是Doxepinhydrochloride的活性代谢产物，Doxepinhydrochloride具有口服活性和抗抑郁作用。

  • GC61147 structure
    GC61147O-desmethyl Mebeverine acid
    CAS: 586357-02-0
    纯度: >98.00%

    A metabolite of mebeverine

  • GC61165 structure
    GC61165Paeoniflorgenin
    CAS: 697300-41-7
    纯度: >90.00%

    Paeoniflorgenin是Paeoniflorin的去糖基化代谢产物。

  • GC61182 structure
    GC61182Phosphoramide mustard (cyclohexanamine)
    CAS: 1566-15-0
    纯度: >95.00%

    An alkylating agent and active metabolite of cyclophosphamide

  • GC61353 structure
    GC61353Trimethoprim N-oxide
    CAS: 27653-68-5

    TrimethoprimN-oxide(Trimethoprim1-N-oxide)属于人尿代谢物。TrimethoprimN-oxide是通过氧化嘧啶环中的氮原子生成的。TrimethoprimN-oxide主要由CYP1A2在人肝微粒体中形成。

  • GC61478 structure
    GC61478N-Desmethyl Pimavanserin
    CAS: 639863-77-7

    N-DesmethylPimavanserin是Pimavanserin的活性代谢物。Pimavanserin是选择性的5-HT2A受体反向激动剂，pIC50和pKd分别为8.73和9.3。

  • GC61536 structure
    GC61536Beclomethasone 17-propionate
    CAS: 5534-18-9
    纯度: >95.00%

    Beclomethasone17-propionate(Beclomethasone-17-monopropionate)是Beclomethasonedipropionate的活性代谢产物，是糖皮质激素受体(GR)激动剂。Beclomethasone17-propionate对GR的亲和力比Beclomethasonedipropionate高。Beclomethasone17-propionate有效抑制慢性阻塞性肺疾病(COPD)肺巨噬细胞中细胞因子的产生。

  • GC61813 structure
    GC61813O-Desmethyl Mebeverine alcohol hydrochloride
    CAS: 856620-39-8
    纯度: >98.00%

    O-DesmethylMebeverinealcoholhydrochloride是Mebeverine的代谢物，Mebeverine是一种有效的α1受体(α1repector)抑制剂，用作消化道的一种解痉药。

  • GC61864 structure
    GC61864DL-Laudanosine
    CAS: 1699-51-0
    纯度: >99.00%

    DL-Laudanosine 是 Atracurium 和 Cisatracurium 的代谢物，可透过血脑屏障，引起兴奋和癫痫发作。

  • GC62033 structure
    GC620333α-Hydroxy pravastatin sodium
    CAS: 81093-43-8

    A metabolite of pravastatin

  • GC62152 structure
    GC62152Homovanillyl alcohol
    CAS: 2380-78-1
    纯度: >99.50%

    Homovanillyl alcohol 是羟基酪醇的生物代谢产物。Hydroxytyrosol 是原始橄榄油 (VOO) 和葡萄酒中存在的一种酚类化合物。Homovanillyl alcohol 可保护红细胞 (RBCs) 免受氧化损伤，并对心血管疾病具有保护作用。