Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products for Drug Metabolite

Cat.No. 产品名称 Information
GC33559 Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant)
奈妥匹坦杂质A,Monohydroxy Netupitant
Monohydroxy Netupitant 是 Netupitant 的代谢物，Netupitant 是一种高选择性的 NK1 受体拮抗剂。
GC33558 Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)
对乙酰氨基酚代谢物; 3-Hydroxyacetaminophen
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)是一种稳定的、羟基化的对乙酰氨基酚中间体。
GC33548 Netupitant metabolite Netupitant N-oxide (Netupitant N-oxide)
奈妥吡坦杂质,Netupitant N-oxide

A metabolite of netupitant
GC33532 Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate)
甲基孕酮,17-Deacetyl norgestimate; 17-Deacylnorgestimate
An active metabolite of norgestimate
GC33495 N-Desmethyl imatinib
N-去甲基伊马替尼; Norimatinib; Imatinib metabolite N-Desmethyl imatinib
A major active metabolite of imatinib
GC33484 Ampyrone (4-Aminoantipyrine)
4-氨基安替比林
4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
GC33452 Niraparib metabolite M1 (Niraparib carboxylic acid metabolite M1)
尼拉帕尼代谢物; Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib
Niraparib 代谢物 M1 (Niraparib carboxy acid metabolite M1) 是 niraparib 的代谢物，后者作为一种新型聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。
GC33438 Hydroxy Itraconazole
羟基伊曲康唑; Itraconazole metabolite Hydroxy Itraconazole; R-63373
A metabolite of itraconazole
GC33333 Regorafénib N-oxyde M2
瑞格非尼 N-氧化物(M2代谢物)杂质13

Regorafénib N-oxyde M2是Regorafenib的一种活性代谢产物。
GC33072 AZ7550 An active metabolite of AZ 9291
GC32535 Modecainide (BMY 40327)
莫地卡尼,BMY 40327; MJ 14030
Modecainide (BMY 40327) 是 Encainide 的主要代谢物，Encainide 是一种抗心律失常药物。
GC32519 Vinburnine ((-)-Eburnamonine)
长春布宁,(-)-Eburnamonine; (-)-Vincamone
Vinburnine ((-)-Eburnamonine, Vincamone, L-Eburnamonine) is a vasodilator. It is a vinca alkaloid and a metabolite of vincamine.
GC32518 Norverapamil hydrochloride ((±)-Norverapamil hydrochloride)
盐酸去甲维拉帕米; (±)-Norverapamil hydrochloride; D591 hydrochloride
An L-type calcium channel blocker
GC32482 Hydroxyhexamide ((±)-Hydroxyhexamid)
乙酸己脲
Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.
GC31734 S-methyl-KE-298 (M-2)
M-2

S-methyl-KE-298 (M-2) 是 KE-298 的活性代谢物。
GC31328 Thyroxine sulfate (T4 Sulfate)
T4磺酸酯,T4 Sulfate
硫酸甲状腺素 (T4 Sulfate) 是一种甲状腺激素代谢物。
GC30994 Vanilpyruvic acid (Vanylpyruvic acid)
4-羟基-3-甲氧基苯基丙酮酸,Vanylpyruvic acid
香草丙酮酸 (Vanylpyruvic acid) 是儿茶酚胺代谢物和香草乳酸的前体。
GC30505 N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride)
去甲氯米帕明-D3盐酸盐,Desmethylclomipramine D3 hydrochloride

N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride) 是氘标记的 N-Desmethyl Clomipramine。
GC19442 15-Acetyldeoxy Nivalenol
15-O-乙酰脱氧瓜萎镰菌醇
A natural mycotoxin
GC18831 Tolmetin β-D-Glucuronide A major phase II metabolite of tolmetin
GC18702 Propiverine N-oxide (hydrochloride) An active propiverine metabolite
GC18654 8-hydroxy Loxapine
8-OH Loxapine
A loxapine metabolite
GC18632 6-hydroxy Bexarotene
6-羟基蓓萨罗丁
An oxidative metabolite of bexarotene
GC18622 (2'S)-Nicotine-1-oxide
(2'S)-尼古丁氧化物
A nicotine metabolite
GC18596 (±)-2-propyl-4-Pentenoic Acid
2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA
A metabolite of valproic acid
GC18582 5'-hydroxy Meloxicam
5'-羟基美洛昔康
A metabolite of meloxicam
GC18569 Propofol β-D-Glucuronide
2,6-二异丙基Β-D-吡喃葡萄糖酸
Propofol β-D-Glucuronide是丙泊酚的代谢产物，被广泛用作鉴定动物体内丙泊酚代谢状态的标志物。
GC18542 5,6-dihydro-5-Fluorouracil
5-氟二氢嘧啶-2,4-二酮
A metabolite of 5-FU
GC18539 4-Hydroxyretinoic acid (4-HRA)
维甲酸杂质
4-Hydroxyretinoic acid (4-HRA)是一种天然存在的，由全反式视黄酸（ATRA）经细胞色素P450酶代谢生成的主要代谢产物。
GC18527 4'-hydroxy Flurbiprofen
4-羟基氟吡洛芬
A major active metabolite of flurbiprofen
GC18466 5,6-epoxy-13-cis Retinoic Acid
异维A酸EP杂质G
A metabolite of 13-cis retinoic acid
GC18455 Digoxigenin Monodigitoxoside
地高辛杂质D
A Na⁺/K⁺-ATPase inhibitor
GC18439 Doxorubicinone
阿霉酮,Adriamycin aglycone; Adriamycinone
A metabolite of doxorubicin
GC18425 4-hydroxy Atorvastatin lactone
P-羟基阿伐他汀内酯
A metabolite of atorvastatin
GC18417 4-hydroxy Xylazine
4-羟基塞拉嗪
A xylazine metabolite
GC18335 6β-hydroxy Dexamethasone
6-羟基地塞米松
A metabolite of dexamethasone
GC18219 6-hydroxy Warfarin
3-(Α-丙酮基苄基)-4,6-二羟基香豆素
A phase I metabolite of (+)-warfarin
GC18194 4-Epidoxycycline
强力霉素
A metabolite of doxycycline
GC15168 Urolithin A
尿石素A
Urolithin A是由鞣花酸和鞣花单宁代谢产生的一种活性成分，可作为酪氨酸酶（IC₅₀值为71.44±10.07µmol/L）和单胺氧化酶A（IC₅₀值为29.41±9.01µmol/L）的强效抑制剂。
GC16333 Cycloguanil (hydrochloride)
环氯胍盐酸盐
The active metabolite of proguanil
GC11989 Nortriptyline (hydrochloride)
盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
A tricyclic antidepressant
GC11155 Omeprazole sulfone
奥美拉唑杂质A,Omeprazole sulfone; Omeprazole sulphone
The major metabolite of omeprazole
GC16553 N-Desmethylclozapine
N-去甲基氯氮平; Norclozapine; Desmethylclozapine; Normethylclozapine
An active metabolite of clozapine
GC16292 Equol
(±)-雌马酚
An estrogen receptor agonist
GC14762 Palifosfamide
帕利伐米,Isophosphoramide mustard;IPM;ZIO-201
An active metabolite of ifosfamide
GC14780 Oseltamivir acid
奥斯他伟酸,GS 4071; Ro 64-0802
A neuraminidase inhibitor and antiviral
GC12685 Ercalcitriol
25-二羟基维生素D2,1α,25-Dihydroxy Vitamin D2
A potent agonist of the vitamin D receptor
GC10822 Clozapine N-oxide (CNO)
氯氮平N-氧化物
Clozapine N-oxide（CNO）是一种强效的多巴胺拮抗剂，也是一种选择性肌动蛋白M4受体（EC50=11 nM）激动剂。