GlpBio

ROR/RAR/RXR

RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

ROR/RAR/RXR 相关产品(88)

  • GC34173 structure
    GC34173LG-100064
    CAS: 153559-46-7
    纯度: >99.50%

    LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。

  • GC34740 structure
    GC34740PROTAC RAR Degrader-1
    CAS: 1351169-27-1

    PROTACRARDegrader-1包含cIAP1配体结合基团，linker和RAR配体结合基团。在HT1080细胞中，PROTACRARDegrader-1降低RAR水平，30μM浓度时达到最大降解程度。同时，基于cIAP1的降解剂也被称为SNIPER。

  • GC34862 structure
    GC34862WYC-209
    CAS: 2131803-90-0
    纯度: >99.50%

    WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

  • GC34960 structure
    GC34960(+)-Talarozole
    CAS: 201410-66-4
    纯度: >99.50%

    (+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。

  • GC35265 structure
    GC35265AGN 195183
    CAS: 367273-07-2
    纯度: >99.50%

    AGN 195183是一种具有口服活性的维甲酸受体α（RARα）选择性激动剂。

  • GC35266 structure
    GC35266AGN 196996
    CAS: 958295-17-5

    AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。

  • GC35267 structure
    GC35267AGN 205327
    CAS: 2070018-29-8

    AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。

  • GC35268 structure
    GC35268AGN 205728
    CAS: 859498-05-8

    AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。

  • GC39584 structure
    GC39584AGN194204
    CAS: 220619-73-8
    纯度: >99.00%

    AGN194204 (IRX4204) 是一种具有口服活性的，选择性 RXR 激动剂，对 RXRα，RXRβ 和 RXRγ 的 Kd 值分别为 0.4 nM，3.6 nM 和 3.8 nM，EC50 分别为 0.2 nM，0.8 nM 和 0.08 nM。AGN194204 对 RAR 无活性，并具有抗炎和抗癌作用。

  • GC40094 structure
    GC40094all-trans Retinoic Acid-d5
    纯度: >99.00%

    An internal standard for the quantification of all-trans retinoic acid

  • GC40464 structure
    GC404649(R)-HETE
    CAS: 107656-14-4
    纯度: >98.00%

    Enantiomer of (±)9-HETE; RXRγ activator

  • GC40465 structure
    GC404659(S)-HETE
    CAS: 107656-13-3
    纯度: >98.00%

    A monohydroxy fatty acid and RXRγ agonist

  • GC42769 structure
    GC42769all-trans Retinoyl β-D-Glucuronide
    CAS: 401-10-5
    纯度: >80.00%

    A metabolite of all-trans retinoic acid

  • GC44059 structure
    GC44059LG 100268
    CAS: 153559-76-3
    纯度: >99.00%

    LG 100268 是一种高效、选择性的视黄醇X受体(RXR)激动剂，EC 50 值为4nM，可强力激活RXR同源二聚体。

  • GC45001 structure
    GC45001Tazarotenic Acid
    CAS: 118292-41-4
    纯度: >98.00%

    An active metabolite of tazarotene

  • GC45567 structure
    GC45567SR 1903
    CAS: 1414248-06-8
    纯度: >98.00%

    A modulator of RORγ and LXR receptors

  • GC46104 structure
    GC46104Butyric Acid-d7
    CAS: 73607-83-7
    纯度: >98.00%

    An internal standard for the quantification of sodium butyrate

  • GC46740 structure
    GC467407β,27-dihydroxy Cholesterol
    CAS: 240129-43-5
    纯度: >95.00%

    An oxysterol and agonist of RORγ and RORγt

  • GC46754 structure
    GC467549(S)-HETE-d8
    CAS: 107656-13-3
    纯度: >99.00%

    A neuropeptide with diverse biological activities

  • GC46798 structure
    GC46798Adapalene-d3
    CAS: 1276433-89-6
    纯度: >99.00%

    An internal standard for the quantification of adapalene

  • GC46892 structure
    GC46892ATRA-BA Hybrid
    CAS: 1037543-26-2
    纯度: >95.00%

    A prodrug form of all-trans retinoic acid and butyric acid

  • GC46923 structure
    GC46923Bexarotene-d4
    CAS: 2182068-00-2
    纯度: >99.00%

    A neuropeptide with diverse biological activities

  • GC49306 structure
    GC49306Isopimaric Acid
    CAS: 5835-26-7
    纯度: >98.00%

    A diterpenoid resin acid

  • GC49393 structure
    GC49393all-trans-13,14-Dihydroretinol
    CAS: 115797-14-3
    纯度: >95.00%

    A metabolite of all-trans retinoic acid