GlpBio

JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

JAK 相关产品(149)

  • GC10035 structure
    GC10035TG101209
    CAS: 936091-14-4
    纯度: >99.50%

    An inhibitor of JAK2, FLT3, RET, and JAK3

  • GC11525 structure
    GC11525Pyridone 6
    CAS: 457081-03-7
    纯度: >98.50%

    吡啶酮 6 抑制 Jak3，K(I)=5 nM； Pyridone 6 还抑制 Jak 家族成员 Tyk2 和 Jak2，IC(50)=1 nM 和 Jak1，IC(50)=15 nM。

  • GC11572 structure
    GC11572Bardoxolone methyl
    CAS: 218600-53-4
    纯度: >98.50%

    Bardoxolone methyl是核因子红细胞2相关因子2（Nrf2）介导的抗氧化和抗炎反应的有效激活剂，也是NF-κB通路的抑制剂。

  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC12083 structure
    GC12083CEP-33779
    CAS: 1257704-57-6
    纯度: >99.00%

    A potent, orally available inhibitor of JAK2

  • GC12118 structure
    GC12118SD 1008
    CAS: 960201-81-4

    SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。

  • GC12454 structure
    GC12454BMS-911543
    CAS: 1271022-90-2

    A potent, selective JAK2 inhibitor

  • GC12504 structure
    GC12504AZD1480
    CAS: 935666-88-9
    纯度: >98.50% / >98.00%

    AZD1480是一种JAK抑制剂（JAK1：IC 50 = 1.3nM；JAK2：IC 50 = 0.4nM） 。

  • GC12579 structure
    GC12579GLPG0634
    CAS: 1206161-97-8
    纯度: >99.50%

    A JAK1 inhibitor

  • GC13347 structure
    GC13347Cucurbitacin I
    CAS: 2222-07-3
    纯度: >98.00%

    Cucurbitacin I是一种选择性的Janus激酶（JAK）/STAT3信号通路抑制剂，在A549细胞中的IC 50 值为500nM。

  • GC13433 structure
    GC13433AZ 960
    CAS: 905586-69-8
    纯度: >98.00%

    A JAK2 inhibitor

  • GC13826 structure
    GC13826JAK2 Inhibitor V, Z3
    CAS: 195371-52-9

    A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK

  • GC13830 structure
    GC13830Baricitinib phosphate
    CAS: 1187595-84-1
    纯度: >99.50%

    A JAK1 and JAK2 inhibitor

  • GC13848 structure
    GC13848LY2784544
    CAS: 1229236-86-5
    纯度: >99.50%

    Potent inhibitor of JAK2

  • GC14191 structure
    GC14191Ruxolitinib (INCB18424)
    CAS: 941678-49-5
    纯度: >98.00%

    Ruxolitinib (INCB18424)作为一种抑制剂，能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50 分别为 3.3 nM 和 2.8 nM，Ruxolitinib介导对造血和免疫功能重要的若干细胞因子和生长因子信号。

  • GC14245 structure
    GC14245ZM 39923 HCl
    CAS: 1021868-92-7
    纯度: >99.50%

    A potent inhibitor of JAK3

  • GC14324 structure
    GC14324TG101348 (SAR302503)
    CAS: 936091-26-8
    纯度: >99.50%

    TG101348 (SAR302503)是一种选择性小分子JAK2抑制剂，IC 50 值为3nM。

  • GC14327 structure
    GC14327XL019
    CAS: 945755-56-6
    纯度: >98.00%

    A potent, bioavailable JAK2 inhibitor

  • GC14671 structure
    GC14671JANEX-1
    CAS: 202475-60-3
    纯度: >98.00%

    A selective JAK3 inhibitor

  • GC14844 structure
    GC14844Baricitinib (LY3009104, INCB028050)
    CAS: 1187594-09-7
    纯度: >99.50%

    Baricitinib (LY3009104, INCB028050)是一种高效口服JAK1/JAK2抑制剂，对JAK1和JAK2的IC 50 值分别为5.9nM和5.7nM。

  • GC15125 structure
    GC15125ZM 449829
    CAS: 4452-06-6

    An inhibitor of JAK3

  • GC15391 structure
    GC15391Cercosporamide
    CAS: 131436-22-1

    A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms

  • GC15589 structure
    GC15589WHI-P154
    CAS: 211555-04-3
    纯度: >99.00%

    A JAK3 inhibitor

  • GC15956 structure
    GC15956WHI-P97
    CAS: 211555-05-4
    纯度: >99.00%

    WHI-P97 是一种有效的选择性 JAK-3 抑制剂。