GlpBio

Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Reactive Oxygen Species 相关产品(453)

  • GC72858 structure
    GC72858Avenanthramide A
    CAS: 108605-70-5
    纯度: >99.00%

    Avenanthramide A是一种可以在燕麦（Avena sativa L）。

  • GC72888 structure
    GC72888CPS-11
    CAS: 145945-21-7
    纯度: >99.00%

    CPS-11（N-（droxymetl）沙利度胺）是沙利度胺类似物，是一种强效抗癌剂。

  • GC72995 structure
    GC72995MnTE-2-PyP chloride
    CAS: 219818-60-7
    纯度: >95.00%

    MnTE-2-PyP chloride是活性氧清除剂和有效的放射性保护剂。

  • GC73031 structure
    GC73031Salpyran dihydrochloride
    纯度: >99.00%

    Salpyran dihydrochloride是一种具有治疗潜力的Cu（II）选择性螯合剂。

  • GC73188 structure
    GC73188SFI003
    CAS: 2361332-90-1
    纯度: >99.00%

    SFI003是一种SRSF3抑制剂，通过SRSF3/DHCR24/ROS轴驱动CRC细胞凋亡，在体外和体内均表现出强大的抗肿瘤作用。

  • GC73212 structure
    GC73212TH-6
    CAS: 3031349-25-1
    纯度: >95.00%

    TH-6是一种强效的HDAC抑制剂，HDAC1、HDAC2、HDAC3、HDAC6、HDAC8的IC50分别为0.115、0.135、0.242、0.138、2.120µM。

  • GC73225 structure
    GC73225ROS-generating agent 1
    CAS: 2369030-41-9
    纯度: >99.00%

    ROS-generating agent 1（化合物2c）共价修饰TrxR的Sec-498残基生成ROS。

  • GC73543 structure
    GC73543FC-116
    CAS: 2417298-29-2
    纯度: >98.00%

    FC-116是一种有效抑制小鼠肿瘤生长的微管蛋白抑制剂。

  • GC74090 structure
    GC74090Dimethyl fumarate-d2
    CAS: 23057-98-9
    纯度: >99.00%

    Dimethyl fumarate-d2是氘标记的富马酸二甲酯。

  • GC74256 structure
    GC74256Condurango glycoside A
    CAS: 11051-90-4
    纯度: >95.00%

    Condurango glycoside A是p53的激活剂。

  • GC74270 structure
    GC74270Penduletin
    CAS: 569-80-2
    纯度: >99.00%

    Penduletin是一种黄酮类化合物，可以从白蜡和牡荆中分离出来。

  • GC74668 structure
    GC746683-Methoxy-9H-Carbazole
    CAS: 18992-85-3
    纯度: >99.00%

    3-Methoxy-9H-Carbazole诱导caspase-3活性和细胞产生活性氧。

  • GC90533 structure
    GC90533(-)-Pinoresinol
    CAS: 81446-29-9
    纯度: >95.00%

    一种具有多种生物活性的木脂素

  • GC90655 structure
    GC90655Lentztrehalose B
    CAS: 1808096-67-4
    纯度: >80.00%

    一种具有多种生物活性的双糖微生物代谢产物。

  • GC90889 structure
    GC908895-(3'-Hydroxyphenyl)-γ-Valerolactone
    CAS: 21618-91-7
    纯度: >95.00%

    多种多酚的代谢产物。

  • GC91083 structure
    GC91083Tiopronin-Cysteine Disulfide
    CAS: 77591-18-5
    纯度: >95.00%

    一种硫普罗宁的代谢产物。

  • GC91099 structure
    GC91099HUP-55
    纯度: >98.00%

    一种脯氨酸内切肽酶抑制剂

  • GC91590 structure
    GC91590DTPD-Q
    CAS: 252950-56-4
    纯度: >98.00%

    DTPD-Q is an oxidized derivative of the antioxidant and methylphenyl substituted p-phenylenediamine DTPD.

  • GC91598 structure
    GC91598GPX4 16
    CAS: 2644044-43-7
    纯度: >98.00%

    GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).

  • GC91673 structure
    GC91673CPPD-Q
    CAS: 68054-78-4
    纯度: >95.00% / >98.00%

    CPPD-Q是一种抗氧化剂CPPD的氧化衍生物，具有抑菌和杀虫作用。

  • GC91783 structure
    GC91783FA16
    纯度: >95.00%

    FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.

  • GC91887 structure
    GC91887Methyl Salicylate-d4
    CAS: 1219802-12-6
    纯度: >99.00%

    Methyl Salicylate-d4用于GC-或LC-MS定量水杨酸甲酯的内部标准。

  • GC91910 structure
    GC91910Ferroptosis Inhibitor D1
    纯度: >98.00%

    Ferroptosis Inhibitor D1是一种自由基清除剂和铁下垂抑制剂。

  • GC92018 structure
    GC92018N,N′-Diferuloylputrescine
    CAS: 42369-86-8
    纯度: >95.00%

    N,N′-Diferuloylputrescine是一种多胺，存在于竹属植物中，具有多种生物活性。