N,N′-Diferuloylputrescine is a polyamine that has been found in Z. mays and has diverse biological activities.1,2,3 It scavenges DPPH, superoxide, and hydroxyl radicals in cell-free assays (IC50s = 38.5, 291.6, and 351.9 ?M, respectively).1 N,N′-Diferuloylputrescine inhibits tyrosinase (IC50 = 291.3 ?M for the mushroom enzyme) and forskolin-induced pigmentation in B16/F10 melanoma cells when used at a concentration of 50 ?g/ml.1,2 It inhibits LPS-induced increases in nitric oxide (NO) and inducible nitric oxide synthase (iNOS) levels, as well as NF-κB activity, in RAW 264.7 macrophages when used at a concentration of 50 ?M.3
References:
[1]. Choi, S.W., Lee, S.K., Kim, E.O., et al.Antioxidant and antimelanogenic activities of polyamine conjugates from corn bran and related hydroxycinnamic acidsJ. Agric. Food Chem.55(10)3920-3925(2007).
[2]. Kim, M.J., Kim, S.M., Im, K.R., et al.Effect of hydroxycinnamic acid derivatives from corn bran on melanogenic protein expressionJ. Korean Soc. Appl. Biol. Chem.53(4)422-426(2010).
[3]. Kim, E.O., Min, K.J., Kwon, T.K., et al.Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated Raw 26.
[4]. 7 macrophagesFood Chem. Toxicol.50(5)1309-1316(2012).