GlpBio

NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

NF-κB 相关产品(233)

  • GC31693 structure
    GC31693Adelmidrol
    CAS: 1675-66-7
    纯度: >98.00%

    Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.

  • GC31706 structure
    GC31706Ginsenoside Rg5
    CAS: 186763-78-0
    纯度: >98.00%

    A ginsenoside with diverse biological activities

  • GC31733 structure
    GC31733NIK SMI1
    CAS: 1660114-31-7
    纯度: >99.50%

    NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.

  • GC31798 structure
    GC31798WAY-204688 (SIM-688)
    CAS: 796854-35-8

    WAY-204688 (SIM-688) 是一种雌激素受体 (ER-α) 选择性、口服活性的 NF-κB 转录活性抑制剂，IC50 为 122±30 nM 作用于 NF-κB-荧光素酶κB-luc) 在 HAECT-1 细胞中。

  • GC31809 structure
    GC31809Yangonin
    CAS: 500-62-9
    纯度: >98.00%

    A kavalactone with affinity for the CB 1 receptor

  • GC31817 structure
    GC31817Ginsenoside Rk3
    CAS: 364779-15-7
    纯度: >98.50% / >98.00%

    Ginsenoside Rk3是从人参或三七中提取的稀有皂苷成分，具有多种生物学功能，可抑制抑制 TNF-α诱导的NF-κB转录活性（IC 50 =14.24±1.30μM）。

  • GC31886 structure
    GC31886Chelidonic acid
    CAS: 99-32-1

    A pyran with diverse biological activities

  • GC32041 structure
    GC32041Triphala
    CAS: 857906-76-4

    Triphala是阿育吠陀的多草药配方，Triphala由三种草本植物Terminaliachebula，Terminaliabellerica，和Phyllanthusemblica组成。Triphala抑制NF-κB活化。Triphala发挥抗真菌(antifungal)作用。具有抗脂肪形成，抗炎，抗肿瘤效果。

  • GC32705 structure
    GC32705(-)-DHMEQ (Dehydroxymethylepoxyquinomicin)
    CAS: 287194-40-5
    纯度: >98.50%

    (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (Dehydroxymethylepoxyquinomicin) 是一种有效、选择性和不可逆的 NF-κB 抑制剂，可与半胱氨酸残基共价结合。

  • GC32737 structure
    GC32737TAK-243 (MLN7243)
    CAS: 1450833-55-2
    纯度: >98.00%

    TAK-243 (MLN7243)是一种选择性泛素活化酶（UBA1）抑制剂，IC 50 值为1nM。

  • GC33150 structure
    GC33150DHMEQ racemate (rel-DHMEQ)
    CAS: 287194-38-1

    DHMEQ 消旋体 (rel-DHMEQ) 是一种 NF-κB 抑制剂。 DHMEQ 消旋体 (rel-DHMEQ) 的活性低于 (-)-DHMEQ。

  • GC33330 structure
    GC33330Cynaropicrin
    CAS: 35730-78-0
    纯度: >98.00%

    A sesquiterpene lactone

  • GC33426 structure
    GC33426Rocaglamide (Rocaglamide A)
    CAS: 84573-16-0
    纯度: >98.50%

    Rocaglamide (Rocaglamide A) 是从 Aglaia 属（楝科）中分离出来的。

  • GC33717 structure
    GC33717Flaconitine (Acetylaconitine)
    CAS: 77181-26-1
    纯度: >98.50%

    A diterpene alkaloid with diverse biological activities

  • GC33831 structure
    GC33831Lidocaine hydrochloride (Lignocaine hydrochloride)
    CAS: 73-78-9
    纯度: >99.50% / >98.00%

    Lidocaine hydrochloride (Lignocaine hydrochloride)是一种氨基酰胺类局部麻醉剂，可抑制voltage-insensitive ‘flicker’ K + channel，IC 50 值为220μM。

  • GC33844 structure
    GC33844Isovitexin (Saponaretin)
    CAS: 38953-85-4
    纯度: >99.50%

    Isovitexin (Saponaretin)是从水稻稻壳中提取的一种物质，具有多种生物活性，包括抗炎和抗氧化活性。

  • GC33861 structure
    GC33861Inulicin (1-O-Acetylbritannilactone)
    CAS: 33627-41-7
    纯度: >98.00% / >99.50%

    A sesquiterpene lactone with diverse biological activities

  • GC34171 structure
    GC34171Tectochrysin (Techtochrysin)
    CAS: 520-28-5
    纯度: >98.00%

    A flavonoid with diverse biological activities

  • GC34556 structure
    GC34556Dendrophenol
    CAS: 108853-14-1

    Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.

  • GC34901 structure
    GC34901DMAPT
    CAS: 870677-05-7
    纯度: >98.00%

    DMAPT(DimethylaminoParthenolide)是Parthenolide(PTL)的水溶性类似物，是具有口服活性的NF-κB抑制剂，对原发性急性髓性白血病细胞的LD50值为1.7μM。具有潜在的抗肿瘤和抗转移作用。

  • GC35143 structure
    GC351434-O-Methyl honokiol
    CAS: 68592-15-4
    纯度: >99.50%

    A phenol with diverse biological activities

  • GC35185 structure
    GC351857,4'-Dihydroxyflavone
    CAS: 2196-14-7
    纯度: >99.00%

    7,4'-Dihydroxyflavone是一种从甘草（Glycyrrhiza uralensis）中分离得到的口服活性黄酮类化合物，可作为嗜酸性粒细胞趋化因子/CCL11和羰基还原酶1（CBR1）的抑制剂。

  • GC35199 structure
    GC351998-Deoxygartanin
    CAS: 33390-41-9

    8-Deoxygartanin 是山竹果中的一种 prenylated xanthones。8-Deoxygartanin 是一种丁基胆碱酯酶 (BChE) 的选择性抑制剂。8-Deoxygartanin 具有抗疟原虫活性，对 Plasmodium falciparum W2 植株作用的 IC50 值为 11.8 μM。8-Deoxygartanin 能抑制 NF-κB (p65) 的活化，IC50 值为 11.3 μM。

  • GC35224 structure
    GC35224Ac2-26 TFA

    Ac2-26 TFA，是膜联蛋白 A1 (AnxA1) 的活性 N-末端肽，可减轻缺血再灌注诱导的急性肺损伤。Ac2-26 还降低 AnxA1 蛋白表达，抑制受损肺组织中 NF-κB 和 MAPK 通路活化。