GlpBio

Flaconitine (Acetylaconitine)

目录号: GC33717纯度: >98.50%同义词: 乙酰乌头碱,Acetylaconitine; 3-Acetylaconitine
A diterpene alkaloid with diverse biological activities
Flaconitine (Acetylaconitine)
Cas No.: 77181-26-1
规格价格库存数量操作
5 mg¥720.00现货
1
10 mg¥1,215.00现货
1
50 mg¥3,060.00现货
1
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产品描述 Description

3-Acetylaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.1,2 It is cytotoxic to P388 leukemia cells (IC50 = 18.6 ?M).1 It inhibits brevetoxin binding to (IC50 = 1.3 ?M), and increases free sodium and calcium concentrations in, rat brain synaptosomes. 3-Acetylaconitine (60-100 nM) induces arrhythmia in isolated guinea pig atria.2 In vivo, 3-acetylaconitine (100 ?g/kg, i.v.) reduces paw licking, flicking, and shaking in a mouse model of formalin-induced inflammatory pain.

1.He, Y.-Q., Yao, B.-H., and Ma, Z.-Y.Diterpenoid alkaloids from a Tibetan medicinal plant Aconitum richardsonianum var. pseudosessiliflorum and their cytotoxic activityJ. Pharm. Anal.1(1)57-59(2011) 2.Gutser, U.T., Friese, J., Heubach, J.F., et al.Mode of antinociceptive and toxic action of alkaloids of Aconitum specNaunyn Schmiedebergs Arch. Pharmacol.375(1)39-48(1997)

实验参考方法 Experimental Reference Method

Cell experiment:

The assay is performed following a standard published procedure using microtiter plate format and sulforhodamine B standing at the end point. The leukemic cells (P388) are exposed to Flaconitine (3-Acetylaconitine) for three days. Cells are grown and maintained in an incubator set at 37°C, 5% CO2 and 95% humidity. RPMI-1640 media supplemented with 10% fetal calf serum (FCS) and 0.5% trypsin are used to culture P388 cells[2].

References:

[1]. Dong L, et al. Identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in Chinese medicinal preparation Fuzilizhong pills using UPLC with quadrupole time-of-flight MS. Phytochem Anal. 2014 Mar-Apr;25(2):113-21.
[2]. He YQ, et al. Diterpenoid alkaloids from a Tibetan medicinal plant Aconitum richardsonianum var. pseudosessiliflorum and their cytotoxic activity. J Pharm Anal. 2011 Feb;1(1):57-59.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
77181-26-1
同义词
乙酰乌头碱,Acetylaconitine; 3-Acetylaconitine
SMILES
CO[C@@H]1C2([C@@](C[C@@]3(O)[C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]4([H])[C@](OC(C)=O)([C@@H](O)[C@@H]3OC)C6C2N(CC)C7)[C@@]([C@H]6OC)([H])[C@@]7(COC)[C@H](OC(C)=O)C1
分子式
C36H49NO12
分子量
687.77 g/mol
溶解性
DMSO : 50 mg/mL (72.70 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol