1-Linoleoyl Glycerol

Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy.^1,2 PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans.³ 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots. It inhibits PAF-AH with an IC₅₀ of 45 ?M.⁴ 1-LG has potential application in cholesterol lowering and antiatherogenic activity.

1.Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorJ. Biol. Chem.265(29)17381-17384(1990) 2.Snyder, F.Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediatorsAm. J. Physiol. Cell Physiol.259(5 Pt 1)C697-C708(1990) 3.Caslake, M.J., and Packard, C.J.Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular diseaseCurr. Opin. Lipidol.14347-352(2003) 4.Lee, W.S., Kim, M.J., Beck, Y.I., et al.Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis rootsBioorg. Med. Chem. Lett.153573-3575(2005)