GlpBio

Cannabidiol dimethyl ether

目录号: GC13816纯度: >98%同义词: CBDD,Cannabidiol-2',6'-dimethyl ether
COASDSData Sheet

Pomalidomide - Peg2-azide is a synthetic E3 ligand -linker conjugate containing Pomalidomide based cereblon ligand and 2-unit PEG linker.

Cannabidiol dimethyl ether
Cas No.: 1242-67-7
规格价格库存数量操作
1mg¥862.00现货
1
5mg¥2,757.00现货
1
10mg¥3,769.00现货
1
50mg¥16,506.00现货
1
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文献被引

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    183(7):1867-1883 (2020)
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产品描述 Description

Pomalidomide - Peg2-azide is a synthetic E3 ligand -linker conjugate containing Pomalidomide based cereblon ligand and 2-unit PEG linker. PROTAC can be synthesized to target protein degradation[1].

The IC50 value of protac compound 21[(BRD4 BD1, IC50 = 41.8 nM) composed of Pomalidomide - Peg2-azide] was 0.81 µM in inhibiting THP-1 cell line growth. At the concentration of 1 µM, compound 21 can effectively degrade BRD4 protein and inhibit c-Myc[1].

References:
[1]. Zhang F, Wu Z, et,al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. doi: 10.1016/j.bmc.2019.115228. Epub 2019 Nov 30. PMID: 31813613.

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

Preparation Method

Reaction Conditions

Applications

Animal experiment [2]:

Animal models

Preparation Method

Dosage form

Applications

References:

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
1242-67-7
同义词
CBDD,Cannabidiol-2',6'-dimethyl ether
化学名
1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-benzene
SMILES
CCCCCc1cc(OC)c(c(OC)c1)[C@@H]1C=C(C)CCC1C(=C)C
分子式
C23H34O2
分子量
342.5 g/mol
溶解性
≤14mg/ml in ethanol;1mg/ml in DMSO;2mg/ml in dimethyl formamide
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol