GlpBio

Interleukin Related

Interleukin Related(白细胞介素相关)

Interleukin is a group of cytokines that mediates cell-cell communication. It plays a critical role in inflammation/immunity and regulates cell proliferation, differentiation and migration etc.

Interleukin Related 相关产品(167)

  • GC31934 structure
    GC31934NFAT Transcription Factor Regulator
    CAS: 245747-71-1
    纯度: >99.00%

    NFAT Transcription Factor Regulator 是一种 IL-2 合成抑制剂，IC50 为 182 nM。

  • GC31948 structure
    GC31948IX 207-887
    CAS: 98320-39-9

    IX207-887是一种新型抗关节炎药物,也能抑制白细胞介素-1(IL-1)的释放。

  • GC33870 structure
    GC33870Veledimex racemate (RG-115932 racemate)
    CAS: 755013-59-3

    Veledimex消旋体（RG-115932消旋体）（INXN-1001消旋体）是veledimex的消旋体。

  • GC33873 structure
    GC33873Nosantine racemate (NPT-15392 racemate)
    CAS: 75166-67-5

    Nosantine 外消旋体 (NPT-15392 racemate) 是 Nosantine 的外消旋体。

  • GC34213 structure
    GC34213Ustekinumab (Anti-Human IL-12/IL-23, Human Antibody)
    CAS: 815610-63-0
    纯度: >98.00%

    Ustekinumab (Stelara, CNTO 1275) is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody used to treat psoriasis. MW=145.6 kDa.

  • GC34371 structure
    GC34371IL-17A antagonist 3
    CAS: 2230780-65-9

    IL-17Aantagonist3是一种IL-17A拮抗剂。

  • GC34372 structure
    GC34372IL-17A antagonist 1
    CAS: 2205034-18-8
    纯度: >99.50%

    IL-17Aantagonist1是一种IL-17A拮抗剂。

  • GC35184 structure
    GC351847,3',4'-Tri-O-methylluteolin
    CAS: 29080-58-8
    纯度: >99.00%

    7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是一种来自草药马鞭草科 (Lippia nodiflora L.) 的类黄酮，Lippia nodiflora L. 已被证明具有抗炎，解热，镇咳，抗糖尿病，抗癌和抗黑素生成特性。7,3',4'-Tri-O-methylluteolin 以浓度依赖方式明显抑制促炎细胞因子，如 TNF-α，IL-6 和 IL-1β。7,3',4'-Tri-O-methylluteolin 显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。

  • GC35214 structure
    GC35214A-9758
    CAS: 2055271-22-0

    A-9758 是一种 RORγ 配体和一种有效选择性的 RORγt 反向激动剂 (IC50 值为 5 nM)，并且强效抑制 IL-17A 释放。A-9758 有效抑制 Th17 分化和 Th17 效应子功能。A-9758 显着减弱 IL-23 驱动型银屑病性皮炎，并有效阻断皮肤和关节炎症。

  • GC35373 structure
    GC35373Apilimod
    CAS: 541550-19-0
    纯度: >98.00%

    Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.

  • GC35374 structure
    GC35374Apilimod mesylate
    CAS: 870087-36-8
    纯度: >99.00%

    Apilimod (STA-5326) mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.

  • GC35440 structure
    GC35440AX-024
    CAS: 1370544-73-2
    纯度: >98.00%

    An inhibitor of the CD3ε-Nck interaction

  • GC35466 structure
    GC35466Balsalazide sodium hydrate
    CAS: 150399-21-6

    A prodrug form of 5-ASA

  • GC36106 structure
    GC36106Gamma-glutamylcysteine (TFA)
    CAS: 283159-88-6

    Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA))是谷胱甘肽 (GSH) 合成的中间体，一种作为抗氧化酶谷胱甘肽过氧化物酶 (GPx) 的必需辅助因子的二肽。 Gamma-glutamylcysteine (TFA) 上调抗炎细胞因子 IL-10 的水平，降低促炎细胞因子 (TNF-α，IL-6 和 IL-1β) 的水平，并减弱在寡聚 Aβ40 处理的星形胶质细胞中金属蛋白酶活性的变化。

  • GC36757 structure
    GC36757NO-prednisolone
    CAS: 327610-87-7
    纯度: >98.50%

    NO-prednisolone 是释放一氧化氮 (NO) 的 Prednisolone 衍生物。NO-prednisolone 有效刺激体内 IL-10 产生。

  • GC37603 structure
    GC37603SC144 hydrochloride
    CAS: 917497-70-2
    纯度: >99.00%

    A gp130 inhibitor

  • GC37705 structure
    GC37705Suramin
    CAS: 145-63-1
    纯度: >98.00%

    A polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities

  • GC37809 structure
    GC37809Tocilizumab
    CAS: 375823-41-9
    纯度: >99.50%

    Tocilizumab 作为一种人源化单克隆抗体，可以靶向 IL-6 受体的膜结合和可溶形式。

  • GC37850 structure
    GC37850Tyrphostin A1
    CAS: 2826-26-8
    纯度: >99.50%

    Tyrphostin A1(AG9)能抑制巨噬细胞培养中CD40L刺激的IL-12产生和抗原诱导的Th1细胞生成。

  • GC37999 structure
    GC37999β-Anhydroicaritin
    CAS: 38226-86-7
    纯度: >98.00%

    β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has antiosteoporosis, estrogen regulation and antitumor properties.

  • GC39070 structure
    GC39070Negletein
    CAS: 29550-13-8

    Negletein 是一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突向外生长。Negletein 通过抑制 TNF-α 和 IL-1β 表现出有希望的抗炎活性，其 IC50 值分别为 16.4 和 10.8 μM。

  • GC39311 structure
    GC39311YQ128
    CAS: 2454246-18-3
    纯度: >99.50%

    An NLRP3 inflammasome inhibitor

  • GC39346 structure
    GC39346Benralizumab
    CAS: 1044511-01-4
    纯度: >99.00%

    Benralizumab (MEDI-563) 是一种白介素 5 受体 α (IL-5Rα) 定向的溶细胞单克隆抗体，通过增强抗体依赖性细胞介导的细胞毒性诱导嗜酸性粒细胞直接，快速和几乎完全耗尽。Benralizumab 可用于严重的嗜酸性哮喘。

  • GC39430 structure
    GC39430Reslizumab
    CAS: 241473-69-8
    纯度: >99.00%

    Reslizumab是一种靶向IL-5分子的人源化IgG4/κ单克隆抗体，K d 值为81pM。