GlpBio

Glucocorticoid Receptor

Glucocorticoid Receptor(糖皮质激素受体)

Glucocorticoid receptor is a neuroendocrine integration that functions as a major component of endocrine influence - specifically the stress response - upon the brain.

Glucocorticoid Receptor 相关产品(95)

  • GC35843 structure
    GC35843Desisobutyryl-ciclesonide
    CAS: 161115-59-9
    纯度: >95.00%

    A glucocorticoid receptor agonist and the active metabolite of ciclesonide

  • GC36268 structure
    GC36268Hydrocortisone cypionate
    CAS: 508-99-6
    纯度: >99.00%

    Hydrocortisone cypionate是一种合成的糖皮质激素和皮质类固醇酯。

  • GC36269 structure
    GC36269Hydrocortisone phosphate
    CAS: 3863-59-0

    Hydrocortisone phosphate 是Cortisol的医药术语, 是一种类固醇激素, 属于糖皮质激素类激素, 通过糖异生增加血糖, 抑制免疫系统，并协助脂肪, 蛋白质和碳水化合物代谢。

  • GC36809 structure
    GC36809OP-3633
    CAS: 2102494-14-2

    OP-3633 是一种高效的甾体糖皮质激素受体 (GR) 拮抗剂，其 IC50 值为 29 nM，具有 GR 转录活性抑制作用。OP-3633 表现出极弱的孕酮受体受体 (PR) 激动作用和雄激素受体 (AR) 拮抗作用。

  • GC36961 structure
    GC36961Prednisolone Tebutate
    CAS: 7681-14-3
    纯度: >98.00%

    Prednisolone tebutate是一种用作抗炎和免疫抑制剂的合成糖皮质激素。

  • GC36962 structure
    GC36962Prednisone acetate
    CAS: 125-10-0
    纯度: >99.50%

    Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.

  • GC38573 structure
    GC38573Dexamethasone palmitate
    CAS: 14899-36-6
    纯度: >98.00%

    地塞米松棕榈酸酯 (DXP) 是地塞米松 (DXM) 的亲脂性前药，是一种糖皮质激素受体激动剂，与糖皮质激素受体的亲和力比 DXM 低 47 倍。

  • GC39222 structure
    GC39222Fluticasone furoate
    CAS: 397864-44-7
    纯度: >99.00%

    A synthetic glucocorticoid

  • GC39362 structure
    GC39362Clobetasone butyrate
    CAS: 25122-57-0
    纯度: >98.00%

    Clobetasone butyrate is a new corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions.

  • GC39363 structure
    GC39363Cortodoxone
    CAS: 152-58-9
    纯度: >98.00% / >99.50%

    Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

  • GC39564 structure
    GC39564Vamorolone
    CAS: 13209-41-1
    纯度: >99.00%

    Vamorolone (VBP15) 是首创的，具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。Vamorolone 改善肌营养不良，无副作用。Vamorolone 抑制 (NF-κB) 抑制作用，并降低了激素的影响。

  • GC40771 structure
    GC40771Fluorometholone
    CAS: 426-13-1
    纯度: >99.00%

    A synthetic glucocorticoid

  • GC40775 structure
    GC40775Dexamethasone
    CAS: 50-02-2
    纯度: >98.00% / >99.00%

    地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。

  • GC42587 structure
    GC425876α-Methylprednisolone 21-hemisuccinate
    CAS: 2921-57-5
    纯度: >98.00%

    A prodrug form of methylprednisolone

  • GC42782 structure
    GC42782Amcinonide
    CAS: 51022-69-6
    纯度: >98.00%

    A synthetic corticosteroid

  • GC44678 structure
    GC44678Prednisolone Phosphate (sodium salt)
    CAS: 125-02-0
    纯度: >97.00%

    A prodrug form of prednisolone

  • GC45994 structure
    GC45994Hydrocortisone Acetate
    CAS: 50-03-3
    纯度: >98.00%

    A synthetic corticosteroid

  • GC60467 structure
    GC6046721-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
    CAS: 37413-91-5
    纯度: >99.50%

    21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione是delta9,11类固醇类合成的中间体(intermediate)，如Vamorolone 。delta9,11steroids是糖皮质激素的修饰后的产物，具有抗炎(anti-inflammatory)特性。delta9,11类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。

  • GC60914 structure
    GC60914Hydrocortisone hemisuccinate
    CAS: 2203-97-6
    纯度: >98.00%

    Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid with anti-inflammatory properties, is an inhibitor of proinflammatory cytokine with IC50 of 6.7 μM and 21.4 μM for Interleukin-6 (IL-6) and IL-3, respectively.

  • GC61536 structure
    GC61536Beclomethasone 17-propionate
    CAS: 5534-18-9
    纯度: >95.00%

    Beclomethasone17-propionate(Beclomethasone-17-monopropionate)是Beclomethasonedipropionate的活性代谢产物，是糖皮质激素受体(GR)激动剂。Beclomethasone17-propionate对GR的亲和力比Beclomethasonedipropionate高。Beclomethasone17-propionate有效抑制慢性阻塞性肺疾病(COPD)肺巨噬细胞中细胞因子的产生。

  • GC61850 structure
    GC61850Medroxyprogesterone acetate D3
    纯度: >98.00%

    Medroxyprogesterone acetate D3 是 Medroxyprogesterone acetate 的氘代物。Medroxyprogesterone acetate 是一种广泛使用的合成类固醇，与孕酮 (progesterone)，雄激素 (androgen) 和糖皮质激素受体 (glucocorticoid receptors) 都有作用。

  • GC62663 structure
    GC62663Glucocorticoid receptor agonist-1
    CAS: 2166375-82-0

    Glucocorticoid receptor agonist-1 是一种有效的选择性 glucocorticoid receptor 激动剂，IC50 为 2.8 nM。详细信息请参考专利文献 WO2017210471A1 中的化合物 41。

  • GC63737 structure
    GC6373721-Desacetyldeflazacort-D5
  • GC63738 structure
    GC63738Deflazacort-D7

    Deflazacort-D7 是 Deflazacort 的氘代物。Deflazacort 是一种糖皮质激素，一种无活性的前药，可迅速转化为活性代谢物 21-Desacetyldeflazacort。Deflazacort 可作为抗炎和免疫抑制剂。