GlpBio

Aurora Kinase

Aurora Kinase(极光激酶)

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

Aurora Kinase 相关产品(62)

  • GC17828 structure
    GC17828BI-847325
    CAS: 1207293-36-4
    纯度: >99.00%

    A selective dual MEK/Aurora kinase inhibitor

  • GC18074 structure
    GC18074PF-03814735
    CAS: 942487-16-3
    纯度: >99.00%

    PF-03814735 是一种有效的、具有口服生物利用度的 Aurora1 和 Aurora2 激酶的可逆抑制剂，IC50 值分别为 0.8nM 和 5nM 。

  • GC19092 structure
    GC19092CCT241736
    CAS: 1402709-93-6
    纯度: >98.00%

    A dual inhibitor of Aurora kinases and FLT3

  • GC25940 structure
    GC25940SNS-314
    CAS: 1057249-41-8

    SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.

  • GC33057 structure
    GC33057LY3295668 (AK-01)
    CAS: 1919888-06-4
    纯度: >98.00%

    LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.

  • GC33379 structure
    GC33379Aurora B inhibitor 1
    CAS: 937276-52-3

    AuroraBinhibitor1是一种AuroraB(Aurora-1)抑制剂，Ki值<0.010uM。详细信息请参考专利文献WO2007059299A1中的化合物1-3。

  • GC34159 structure
    GC34159Ilorasertib (ABT-348)
    CAS: 1227939-82-3

    A multi-kinase inhibitor

  • GC34692 structure
    GC34692NU6140
    CAS: 444723-13-1
    纯度: >99.50%

    A Cdk2 inhibitor

  • GC35216 structure
    GC35216AAPK-25
    CAS: 2247919-28-2

    AAPK-25 是一种有效选择性的 Aurora/PLK 激酶双重抑制剂，具有抗肿瘤活性。AAPK-25 可引起有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10 磷酸化反应，随后细胞凋亡激增。AAPK-25 靶向 Aurora-A, -B, -C 的 Kd 值为 23 nM-289 nM，靶向 PLK-1, -2, -3 的 Kd 值为 55-456 nM。

  • GC35651 structure
    GC35651Cenisertib
    CAS: 871357-89-0
    纯度: >99.50%

    Cenisertib (AS-703569) 是一种多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。

  • GC37606 structure
    GC37606SCH-1473759 hydrochloride
    CAS: 1094067-13-6
    纯度: >99.50%

    SCH-1473759 hydrochloride是多靶点的的极光激酶 (aurora) 抑制剂，对极光激酶A和B的IC50 值分别为4 和13 nM。

  • GC38519 structure
    GC38519Ilorasertib hydrochloride
    CAS: 1847485-91-9
    纯度: >98.50%

    A multi-kinase inhibitor

  • GC40667 structure
    GC40667Aurora Kinase Inhibitor II
    CAS: 331770-21-9
    纯度: >99.00%

    Blocks Aurora A kinase activity

  • GC42933 structure
    GC42933Binucleine 2
    CAS: 220088-42-6
    纯度: >98.00%

    An inhibitor of Drosophila Aurora B kinase

  • GC48971 structure
    GC48971AZD 1152 (hydrochloride)
    CAS: 722543-50-2
    纯度: >95.00%

    A prodrug for a potent Aurora B inhibitor

  • GC48982 structure
    GC48982CD532
    CAS: 1639009-81-6
    纯度: >98.00%

    An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction

  • GC50050 structure
    GC50050Hesperadin hydrochloride

    A multi-kinase inhibitor

  • GC62145 structure
    GC62145Chiauranib
    CAS: 1256349-48-0
    纯度: >99.00%

    Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.

  • GC62189 structure
    GC62189CD532 hydrochloride
    纯度: >99.00%

    An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction

  • GC62433 structure
    GC62433AKI603
    CAS: 1432515-73-5
    纯度: >98.00%

    AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.

  • GC62482 structure
    GC62482TAS-119
    CAS: 1453099-83-6
    纯度: >98.00%

    TAS-119 是一种有效的，选择性的，具有口服活性的 Aurora A 抑制剂，IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶，包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。

  • GC67899 structure
    GC67899Aurora kinase inhibitor-8
    CAS: 2133001-88-2

    Aurora kinase inhibitor-8 是一种高选择性 Aurora 激酶的抑制剂。

  • GC68147 structure
    GC68147dAURK-4 hydrochloride

    dAURK-4 hydrochloride 是 Alisertib 的一种衍生物，是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 hydrochloride 具有抗癌作用。

  • GC69068 structure
    GC69068ENMD-2076 Tartrate
    CAS: 1453868-32-0
    纯度: >99.00%

    ENMD-2076 Tartrate 是多靶点激酶抑制剂，抑制 Aurora A，Flt3，KDR/VEGFR2，Flt4/VEGFR3，FGFR1，FGFR2，Src，PDGFRα 的IC50 值分别为1.86，14，58.2，15.9，92.7，70.8，20.2 and 56.4 nM。