GlpBio

Aurora Kinase

Aurora Kinase(极光激酶)

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

Aurora Kinase 相关产品(62)

  • GC70030 structure
    GC70030Tinengotinib
    CAS: 2230490-29-4

    Tinengotinib 是一种或多种蛋白激酶的调节剂，例如 Aurora 激酶和 VEGFR 激酶。Tinengotinib 具有研究这些激酶异常介导的疾病的潜力，尤其是癌症相关疾病 (摘自专利 WO2018108079A1)。

  • GC72964 structure
    GC72964Aurkin A
    CAS: 1534060-58-6
    纯度: >98.00%

    Aurkin A是极光A激酶（Aurora A Kinase，也称Aurka）与TPX2相互作用的变抗抑制剂，通过靶向TPX2结合位点，Kd为3.77 μM。

  • GC73375 structure
    GC73375Aurora Kinases-IN-3
    CAS: 2840558-83-8
    纯度: >98.00%

    Aurora Kinases-IN-3（化合物15a）是一种口服活性AURKB抑制剂，通过破坏AURKB的有丝分裂定位来引发AURKB抑制活性。

  • GC73744 structure
    GC73744JAB-2485
    CAS: 2899209-55-1
    纯度: >98.00%

    JAB-2485是一种有效的选择性极光激酶a （AURKA）抑制剂，IC50为0.33 nM。

  • GC73753 structure
    GC73753EGFR/AURKB-IN-1
    CAS: 3008543-34-5
    纯度: 不显示

    EGFR/AURKB-IN-1（化合物7）是双靶向EGFR/AURKB抑制剂，抑制L858R EGFR和AURKB的磷酸化，ic50值分别为0.07和1.1。

  • GC74000 structure
    GC74000DBPR728
    CAS: 2702965-64-6
    纯度: >98.00%

    DBPR728是6K465的酰基前药，携带较少的氢键供体。

  • GC11310 structure
    GC11310CCT129202
    CAS: 942947-93-5
    纯度: >98.00%

    An Aurora kinase inhibitor

  • GC12208 structure
    GC12208MLN8054
    CAS: 869363-13-3
    纯度: >99.00%

    An inhibitor of Aurora A kinase

  • GC12612 structure
    GC12612JNJ-7706621
    CAS: 443797-96-4
    纯度: >99.50%

    A dual inhibitor of CDKs and Aurora kinases

  • GC15217 structure
    GC15217Danusertib (PHA-739358)
    CAS: 827318-97-8
    纯度: >98.50%

    A pan-Aurora kinase and Abl inhibitor

  • GC10638 structure
    GC10638AT9283
    CAS: 896466-04-9
    纯度: >99.50%

    A broad spectrum kinase inhibitor

  • GC17162 structure
    GC17162MK-5108 (VX-689)
    CAS: 1010085-13-8
    纯度: >98.00%

    MK-5108 (VX-689)是一种有效的ATP竞争性Aurora A激酶抑制剂，IC 50 值为0.064nM。

  • GC10479 structure
    GC10479PHA-680632
    CAS: 398493-79-3
    纯度: >99.50%

    An Aurora kinase inhibitor

  • GC17284 structure
    GC17284Anacardic acid
    CAS: 16611-84-0
    纯度: >98.00%

    A histone acetyltransferase inhibitor