dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects[1].
dAURK-4 (125-1000 nM; 4-24 hours) hydrochloride shows degradation of AURKA in a dose-depended manner[1].
Cell Viability Assay[1]
| Cell Line: | MM.1S cells |
| Concentration: | 125 nM, 250 nM, 500 nM, 1000 nM |
| Incubation Time: | 4 hours or 24 hours |
| Result: | Inhibited the protein level of AURKA (Aurora A). |
[1]. Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.