Topoisomerase
Topoisomerase(拓扑异构酶)
Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.
Topoisomerase 相关产品(182)
- GC38194(±)-10-HydroxycamptothecinCAS: 64439-81-2纯度: >98.00%
Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
- GC38511GroenlandicineCAS: 38691-95-1纯度: >99.50%
Groenlandicine 是从黄连中分离得到的一种原小檗碱生物碱。Groenlandicine 对人类重组醛糖还原酶 (HRAR) 具有中度的抑制作用，IC50 值为 154.2 μM。Groenlandicine 能诱导拓扑异构酶 I (topoisomerase I) 介导的 DNA 裂解。
- GC39425Proscillaridin ACAS: 466-06-8纯度: >99.50%
Proscillaridin A 是强力的拓扑异构酶 I 和 II topoisomerase I/II 抑制剂，抑制拓扑异构酶 I 和 II 的 IC50 值分别为 30 nM 和 100 nM。
- GC39699Aurintricarboxylic acidCAS: 4431-00-9
A protein synthesis inhibitor with diverse biological activities
- GC453679-Hydroxyellipticine (hydrochloride)CAS: 52238-35-4纯度: >95.00%
An ellipticine derivative with diverse biological activities
- GC45888Topotecan-d6CAS: 1044904-10-0纯度: >99.00%
An internal standard for the quantification of topotecan
- GC45998Mitoxantrone-d8CAS: 1189974-82-0纯度: >99.00%
An internal standard for the quantification of mitoxantrone
- GC48664Enoxacin-d8 (hydrochloride)CAS: 2930288-95-0纯度: >99.00%
An internal standard for the quantification of enoxacin
- GC49134Flumequine-13C3CAS: 1185049-09-5纯度: >98.00%
An internal standard for the quantification of flumequine
- GC49308UngeremineCAS: 2121-12-2纯度: >98.00%
A betaine-type alkaloid with diverse biological activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38194 | (±)-10-Hydroxycamptothecin | 64439-81-2 | >98.00% | |
Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. | ||||
| GC38511 | Groenlandicine | 38691-95-1 | >99.50% | |
Groenlandicine 是从黄连中分离得到的一种原小檗碱生物碱。Groenlandicine 对人类重组醛糖还原酶 (HRAR) 具有中度的抑制作用，IC50 值为 154.2 μM。Groenlandicine 能诱导拓扑异构酶 I (topoisomerase I) 介导的 DNA 裂解。 | ||||
| GC38774 | DRF-1042 | 200619-13-2 | >98.00% | |
DRF-1042 是一种具有口服活性的喜树碱类似物，具有抑制 DNA 拓扑异构酶 I (DNA topoisomerase I) 的作用。DRF-1042 对一组人癌细胞株，包括多药耐药 (MDR)表型，显示出良好的抗癌活性。 | ||||
| GC39425 | Proscillaridin A | 466-06-8 | >99.50% | |
Proscillaridin A 是强力的拓扑异构酶 I 和 II topoisomerase I/II 抑制剂，抑制拓扑异构酶 I 和 II 的 IC50 值分别为 30 nM 和 100 nM。 | ||||
| GC39699 | Aurintricarboxylic acid | 4431-00-9 | - | |
A protein synthesis inhibitor with diverse biological activities | ||||
| GC40195 | Etoposide-d3 | - | >99.00% | |
An internal standard for the quantification of etoposide | ||||
| GC41643 | 9(Z),11(E),13(E)-Octadecatrienoic Acid | 506-23-0 | >95.00% | |
A polyunsaturated fatty acid | ||||
| GC42783 | Ametantrone | 64862-96-0 | >90.00% | |
An inhibitor of topoisomerase II | ||||
| GC42912 | Becatecarin | 119673-08-4 | >98.00% | |
A water-soluble antineoplastic antibiotic | ||||
| GC43565 | Doxorubicinol (hydrochloride) | 63950-05-0 | >90.00% | |
A doxorubicin metabolite | ||||
| GC44651 | Pixantrone (maleate) | 144675-97-8 | >98.00% | |
A DNA topoisomerase II inhibitor | ||||
| GC44809 | Rebeccamycin | 93908-02-2 | >99.00% | |
A DNA topoisomerase I inhibitor | ||||
| GC45009 | Temafloxacin | 108319-06-8 | >99.50% | |
A DNA topoisomerase inhibitor | ||||
| GC45367 | 9-Hydroxyellipticine (hydrochloride) | 52238-35-4 | >95.00% | |
An ellipticine derivative with diverse biological activities | ||||
| GC45886 | Levofloxacin-d8 (hydrochloride) | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC45888 | Topotecan-d6 | 1044904-10-0 | >99.00% | |
An internal standard for the quantification of topotecan | ||||
| GC45998 | Mitoxantrone-d8 | 1189974-82-0 | >99.00% | |
An internal standard for the quantification of mitoxantrone | ||||
| GC46113 | CAY10744 | 2375613-31-1 | >98.00% | |
A topoisomerase II-α poison | ||||
| GC46880 | ARN24139 | 2699768-78-8 | >98.00% | |
A topoisomerase II poison | ||||
| GC47098 | CL2-SN-38 (dichloroacetic acid salt) | - | >98.00% | |
An antibody-drug conjugate containing SN-38 | ||||
| GC48664 | Enoxacin-d8 (hydrochloride) | 2930288-95-0 | >99.00% | |
An internal standard for the quantification of enoxacin | ||||
| GC49134 | Flumequine-13C3 | 1185049-09-5 | >98.00% | |
An internal standard for the quantification of flumequine | ||||
| GC49308 | Ungeremine | 2121-12-2 | >98.00% | |
A betaine-type alkaloid with diverse biological activities | ||||
| GC49760 | SN-38 Glucuronide | 121080-63-5 | >98.00% | |
A phase II metabolite of irinotecan | ||||