GlpBio

PARP

PARP(多聚ADP核糖聚合酶)

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

PARP 相关产品(120)

  • GC17965 structure
    GC17965AZD2461
    CAS: 1174043-16-3
    纯度: >98.00%

    A PARP inhibitor

  • GC10456 structure
    GC10456Fucosterol
    CAS: 17605-67-3
    纯度: >98.00%

    A natural phytosterol with diverse biological activities

  • GC11761 structure
    GC117614-amino-1,8-Naphthalimide
    CAS: 1742-95-6
    纯度: >98.00%

    A PARP inhibitor

  • GC12781 structure
    GC12781XAV-939
    CAS: 284028-89-3
    纯度: >98.50% / >98.00%

    XAV-939 选择性抑制 β-连环蛋白介导的转录。

  • GC12844 structure
    GC12844Benzamide
    CAS: 55-21-0
    纯度: >99.50%

    Benzamide (Benzenecarboxamide) 是一种有效的聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。

  • GC13249 structure
    GC13249Rucaparib (free base)
    CAS: 283173-50-2
    纯度: >99.00%

    Rucaparib (free base)是一种口服生物可利用的三环吲哚类聚（ADP-核糖）聚合酶（PARP）抑制剂。

  • GC13541 structure
    GC13541G007-LK
    CAS: 1380672-07-0
    纯度: >99.00%

    G007-LK是一种有效的、选择性的TNKS1（IC 50 =46nM）和TNKS2（IC 50 =25nM）抑制剂。

  • GC14251 structure
    GC14251Picolinamide
    CAS: 1452-77-3

    poly (ADP-ribose) synthetase inhibitor

  • GC14380 structure
    GC14380BGP-15
    CAS: 66611-37-8
    纯度: >98.00%

    A PARP inhibitor and insulin sensitizer

  • GC15932 structure
    GC15932BMN 673
    CAS: 1207456-01-6
    纯度: >98.50%

    BMN 673是一种新型且高效的聚ADP核糖聚合酶1和2（PARP1/2）抑制剂，对PARP1的K i 为1.2nM，对PARP2的K i 为0.87nM。

  • GC15955 structure
    GC15955Rucaparib (AG-014699,PF-01367338) phosphate
    CAS: 459868-92-9
    纯度: >99.50%

    Rucaparib (AG-014699,PF-01367338) phosphate是一种口服生物可利用的三环吲哚类聚（ADP-核糖）聚合酶（PARP）抑制剂。

  • GC16318 structure
    GC16318AG-14361
    CAS: 328543-09-5
    纯度: >99.00%

    A PARP1 inhibitor

  • GC16725 structure
    GC16725AZ6102
    CAS: 1645286-75-4
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC16914 structure
    GC16914MN 64
    CAS: 92831-11-3
    纯度: >99.50%

    A TNKS inhibitor

  • GC17555 structure
    GC17555NVP-TNKS656
    CAS: 1419949-20-4
    纯度: >98.00%

    A TNKS2 inhibitor

  • GC18172 structure
    GC18172E7449
    CAS: 1140964-99-3
    纯度: >98.00%

    An inhibitor of PARP1, PARP2, and TNKS1/2

  • GC19264 structure
    GC19264NMS-P118
    CAS: 1262417-51-5
    纯度: >99.50%

    A potent and selective PARP1 inhibitor

  • GC19505 structure
    GC19505RK-287107
    CAS: 2171386-10-8
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC19542 structure
    GC19542GeA-69
    CAS: 2143475-98-1
    纯度: >99.50%

    GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。

  • GC32793 structure
    GC32793Rucaparib Camsylate
    CAS: 1859053-21-6
    纯度: >99.50%

    A PARP1 inhibitor

  • GC33223 structure
    GC33223BRCA1-IN-1
    CAS: 1622262-74-1

    BRCA1-IN-1是一种新型的小分子BRCA1抑制剂，IC50和Ki分别为0.53μM和0.71μM。

  • GC33358 structure
    GC33358WD2000-012547
    CAS: 283172-68-9

    WD2000-012547是一种选择性的PARP-1抑制剂，pKi为8.221。

  • GC34071 structure
    GC34071Pamiparib (BGB-290)
    CAS: 1446261-44-4
    纯度: >99.50%

    Pamiparib (BGB-290)是一种强效口服的聚腺苷二磷酸核糖聚合酶（PARP）抑制剂，对PARP-1和PARP-2的IC 50 值分别为1.3nM和0.9nM。

  • GC34120 structure
    GC34120Niraparib R-enantiomer (MK 4827 (R-enantiomer))
    CAS: 1038915-58-0
    纯度: >99.50%

    Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂，IC50 为 2.4 nM。