GlpBio

RIP kinase

RIP kinase(受体相互作用蛋白激酶)

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing TRIF or DAI. RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase 相关产品(52)

  • GC37536 structure
    GC37536RIPK1-IN-7
    CAS: 2300982-44-7
    纯度: >98.50%

    RIPK1-IN-7 is a potent and selective receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM.

  • GC37537 structure
    GC37537RIPK-IN-4
    CAS: 2141969-56-2
    纯度: >99.00%

    RIPK-IN-4 是一种有效选择性的、具有良好的口服生物利用度的 RIPK2 抑制剂，IC50 值为 3 nM。

  • GC38037 structure
    GC38037GSK2983559 free acid
    CAS: 1579965-12-0
    纯度: >99.50%

    A RIPK2 inhibitor

  • GC38841 structure
    GC38841RIPK1-IN-4
    CAS: 1481641-08-0
    纯度: >98.00%

    RIPK1-IN-4 (compound 8) 是一种有效的 II 型激酶受体相互作用蛋白1 (RIP1) 激酶抑制剂，并且与 DL1-out 无活性形式的 RIP1 结合，对于 RIP1 和 ADP-Glo 激酶，IC50 为分别为 16 nM 和 10 nM。

  • GC49556 structure
    GC49556Cl-Necrostatin-1
    CAS: 862377-51-3
    纯度: >95.00%

    A RIPK1 inhibitor

  • GC50517 structure
    GC50517OD 36 hydrochloride
    CAS: 1638644-62-8
    纯度: >99.50%

    OD 36 hydrochloride是一种强效的RIPK2激酶抑制剂，IC 50 值为5.3nM。

  • GC60307 structure
    GC60307PROTAC RIPK degrader-2
    CAS: 1801547-16-9
    纯度: >99.00%

    PROTAC RIPK degrader-2 是一种非肽性PROTAC，它以丝氨酸苏氨酸激酶 RIPK2 为靶点，对 RIPK2 的降解具有高度选择性。

  • GC61215 structure
    GC61215PROTAC RIPK degrader-6
    CAS: 2089205-64-9
    纯度: >99.00%

    PROTACRIPKdegrader-6(example1)是一种PROTAC类的有效RIPK降解剂。

  • GC62316 structure
    GC62316Necrostatin-34
    CAS: 375835-43-1
    纯度: >98.50%

    Necrostatin-34 (Nec-34) is a small molecule inhibitor of RIPK1 kinase with an IC50 of 0.13 μM in L929 cells.

  • GC62455 structure
    GC62455RIPK3-IN-1
    CAS: 2361139-70-8
    纯度: >98.50%

    RIPK3-IN-1 是 II 型 RIPK3 DFG-out 位点抑制剂，IC50 为 9.1 nM。RIPK3-IN-1 抑制 RIPK1 和 RIPK2，IC50 为 5.5 和 >10 μM。RIPK3-IN-1 还是 c-Met 激酶抑制剂，IC50 为 1.1 μM。

  • GC62626 structure
    GC62626ICCB-19 hydrochloride
    CAS: 1803605-68-6
    纯度: >99.00%

    ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.

  • GC62997 structure
    GC62997GSK-872 hydrochloride
    CAS: 2703752-81-0
    纯度: >99.50% / >99.00% / >98.00%

    A selective inhibitor of RIPK3

  • GC63470 structure
    GC63470Eclitasertib
    CAS: 2125450-76-0

    Eclitasertib (DNL-758) 是一种受体相互作用蛋白激酶1 (RIPK1) 抑制剂，IC50 值为 <1 µμ（来自专利WO2017136727A2，example 42)。

  • GC64370 structure
    GC64370Kongensin A
    CAS: 885315-96-8
    纯度: >98.00%

    Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。

  • GC64951 structure
    GC64951GSK963
    CAS: 2049868-46-2
    纯度: >99.00%

    GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10?000-fold selective for RIP1 over 339 other kinases.

  • GC65004 structure
    GC65004Apostatin-1
    CAS: 2559703-06-7
    纯度: >99.00%

    Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apostatin-1 inhibits bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.

  • GC65467 structure
    GC65467RIPK1-IN-10
    CAS: 2682889-51-4
    纯度: >98.00%

    RIPK1-IN-10 是一种有效的 RIPK1 抑制剂，例 37，提取自专利 WO2021160109。

  • GC65967 structure
    GC65967RIP2 Kinase Inhibitor 3
    CAS: 1398053-50-3

    RIP2 Kinase Inhibitor 3 是一种高效、选择性的受体相互作用蛋白 -2 (RIP2) 激酶抑制剂，IC50 值为 1 nM。

  • GC66479 structure
    GC66479GSK2593074A
    CAS: 1337531-06-2
    纯度: >98.00%

    GSK2593074A (GSK'074) 是一种程序性坏死 (necroptosis) 抑制剂, 抑制 RIP1 和 RIP3。

  • GC67969 structure
    GC67969RIP1/RIP3/MLKL activator 1
    CAS: 2682850-41-3

    RIP1/RIP3/MLKL activator 1 (Compound 6i) 是一种有效的抗胶质瘤 (anti-glioma) 药物。RIP1/RIP3/MLKL activator 1 通过激活 RIP1/RIP3/MLKL 通路诱导细胞坏死 （Necroptosis）。 RIP1/RIP3/MLKL activator 1 可透过血脑屏障。

  • GC68903 structure
    GC68903cRIPGBM chloride
    CAS: 2361988-77-2
    纯度: >99.00%

    cRIPGBM chloride 是一种口服有效的促凋亡衍生物，cRIPGBM 可从多形性胶质母细胞瘤 (GBM) 癌症干细胞 (CSC) 中产生。cRIPGBM chloride 靶向受体相互作用蛋白激酶 2 (RIPK2) 以诱导半胱天冬酶 caspase 1 依赖性细胞凋亡。cRIPGBM chloride 抑制 RIPK2/TAK1 (促存活复合物) 的形成，并增加 RIPK2/caspase 1 (促凋亡复合物) 的形成。cRIPGBM chloride 在动物模型中发挥了强力的体内抗肿瘤活性。

  • GC70875 structure
    GC70875RIPK1-IN-9
    CAS: 2682889-57-0
    纯度: 不显示

    RIPK1-IN-9（实施例45）是一种二氢萘啶酮化合物，是一种强效且选择性的RIPK1抑制剂。

  • GC71050 structure
    GC71050Oditrasertib
    CAS: 2252271-93-3
    纯度: >98.00%

    Oditrasertib是一种IC50值低于100nM的受体相互作用蛋白激酶1（RIPK1）抑制剂。

  • GC71180 structure
    GC71180SZM679
    CAS: 3027645-52-6
    纯度: >99.00%

    SZM679是一种强效、口服活性和选择性的RIPK1抑制剂，RIPK1和RIPK3的Kd值分别为8.6 nM和>5000 nM。