GlpBio

RIP kinase

RIP kinase(受体相互作用蛋白激酶)

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing TRIF or DAI. RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase 相关产品(52)

  • GC11008 structure
    GC11008Necrostatin-1
    CAS: 4311-88-0
    纯度: >98.00% / >99.00%

    Necrostatin-1主要作用于细胞中的RIP1，Necrostatin-1是一种RIP1激酶抑制剂，IC50值为0.32 mM。

  • GC11167 structure
    GC11167Necrostatin 2
    CAS: 852391-19-6
    纯度: >99.50%

    A potent inhibitor of necroptosis

  • GC15291 structure
    GC15291GSK3145095
    CAS: 1622849-43-7
    纯度: >98.00%

    GSK3145095 是一种 RIP1 激酶抑制剂，IC50 为 6.3 nM。

  • GC15573 structure
    GC15573GSK481
    CAS: 1622849-58-4
    纯度: >98.00%

    A selective inhibitor of RIP1

  • GC18177 structure
    GC18177WEHI-345
    CAS: 1354825-58-3
    纯度: >99.00%

    An inhibitor of RIPK2

  • GC19175 structure
    GC19175GSK-872
    CAS: 1346546-69-7
    纯度: >99.50%

    GSK-872 是一种 RIPK3 抑制剂。

  • GC19182 structure
    GC19182GSK2982772
    CAS: 1622848-92-3
    纯度: >99.00%

    A RIPK1 inhibitor

  • GC19185 structure
    GC19185GSK583
    CAS: 1346547-00-9
    纯度: >98.50%

    A selective inhibitor of RIP2 kinase

  • GC19503 structure
    GC19503GSK547
    CAS: 2226735-55-1
    纯度: >99.50%

    GSK547 (GSK'547) 是受体相互作用的丝氨酸/苏氨酸蛋白激酶 1 (RIPK1) 的高选择性和强效抑制剂，可抑制巨噬细胞介导的胰腺癌适应性免疫耐受。

  • GC31652 structure
    GC31652RIPA-56
    CAS: 1956370-21-0
    纯度: >99.50%

    A RIPK1 inhibitor

  • GC32280 structure
    GC32280HS-1371
    CAS: 2158197-70-5
    纯度: >97.00%

    A RIPK3 inhibitor

  • GC32775 structure
    GC32775RIP2 kinase inhibitor 1
    CAS: 1423186-80-4
    纯度: >98.50%

    GSK2983559 active metabolite is an active metabolite of GSK2983559, also is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

  • GC32860 structure
    GC32860RIP2 kinase inhibitor 2
    CAS: 1581270-11-2
    纯度: >99.50%

    RIP2kinaseinhibitor2是一种受体相互作用蛋白-2(RIP2)激酶抑制剂，详细信息请参考专利WO/2014043437A1中的化合物example9。

  • GC33620 structure
    GC33620Nec-4
    CAS: 1041644-43-2

    Nec-4,一个三环衍生物，是受体相互作用蛋白1(RIP1)的一个有效抑制剂，其IC50值为2.6μM，Ki值为0.46μM。

  • GC34543 structure
    GC34543cRIPGBM
    CAS: 2361988-76-1

    cRIPGBM是RIPGBM的促凋亡衍生物，是通过与受体相互作用蛋白激酶2(RIPK2)结合，诱导GBM肿瘤干细胞凋亡的选择性诱导剂，对GBM-1细胞的EC50值为68nM。

  • GC34605 structure
    GC34605GSK840
    CAS: 2361146-30-5
    纯度: >99.00%

    GSK840(GSK’840)是一种受体相互作用蛋白激酶3(RIP3orRIPK3)抑制剂，高亲和力结合RIP3激酶结构域，IC50值为0.9nM，并抑制激酶活性，IC50值为0.3nM。

  • GC34606 structure
    GC34606GSK-843
    CAS: 1601496-05-2
    纯度: >98.00%

    GSK-843是一种受体相互作用蛋白激酶3(RIP3orRIPK3)抑制剂，高亲和力结合RIP3激酶结构域，IC50值为8.6nM，并抑制激酶活性，IC50值为6.5nM。

  • GC36170 structure
    GC36170GNE684
    CAS: 2438637-64-8

    GNE684 是一种有效的受体相互作用蛋白 1 (RIP1) 抑制剂，作用于人类、小鼠与大鼠 RIP1 的 Kiapp 值分别为 21 nM、189 nM 和 691 nM。

  • GC36189 structure
    GC36189GSK2983559
    CAS: 1579965-12-0
    纯度: >98.00%

    A RIPK2 inhibitor

  • GC36711 structure
    GC36711Necrostatin 2 racemate
    CAS: 852391-15-2
    纯度: >99.50%

    Necrostatin 2 racemate是一种不影响吲哚胺2,3-双加氧酶（IDO）活性的，具有高度特异性的受体相互作用蛋白激酶1（RIPK1）抑制剂。

  • GC36712 structure
    GC36712Necrostatin 2 S enantiomer
    CAS: 852391-20-9
    纯度: >99.50%

    Necrostatin 2 S enantiomer 是 Necrostatin 2 的 S 型异构体。Necrostatin 2 是高活性的坏死性凋亡抑制剂，为有效的 RIPK1 抑制剂，缺乏 IDO 靶向作用。

  • GC36933 structure
    GC36933PK68
    CAS: 2173556-69-7
    纯度: >99.50%

    PK68 is a potent orally active and specific inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM.

  • GC37533 structure
    GC37533RIP1 kinase inhibitor 1
    CAS: 2095515-38-9
    纯度: >99.50%

    RIP1 kinase inhibitor 1 (compound 22) 是一种高效的，口服有效的，可穿透大脑的 RIP1 激酶抑制剂 (pKi=9.04)。

  • GC37535 structure
    GC37535RIPK1-IN-3
    CAS: 2242677-36-5

    RIPK1-IN-3 (Example 38) 是RIPK1 的抑制剂，信息来自专利WO2018148626A1，拥有抗炎活性。