HS-1371 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 20.8 nM).1 It inhibits basal RIPK3 autophosphorylation and TNF-α- or TRAIL-induced necroptosis in HT-29 cells when used at a concentration of 5 ?M. It also inhibits necroptosis induced by a TNF-α Smac mimetic and the caspase inhibitor Z-VAD in HeLa cervical and NCI-H2009 lung cancer cells ectopically expressing RIPK3.
1.Park, H.-H., Park, S.-Y., Mah, S., et al.HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosisExp. Mol. Med.50(9)1-15(2018)