GlpBio

GSK-872 hydrochloride

目录号: GC62997纯度: >98.00%
A selective inhibitor of RIPK3
GSK-872 hydrochloride
Cas No.: 2703752-81-0
规格价格库存数量操作
1mg¥308.00现货
1
5mg¥774.00现货
1
10mg¥1,305.00现货
1
25mg¥2,430.00现货
1
50mg¥3,402.00现货
1
100mg¥4,766.00现货
1
10mM (in 1mL DMSO)¥851.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

GSK872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3).1 It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 μM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced by toll-like receptor 3 (TLR3).

1.Kaiser, W.J., Sridharan, H., Huang, C., et al.Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKLJ. Biol. Chem.288(43)31268-31279(2013)

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2703752-81-0
分子式
C19H18ClN3O2S2
分子量
419.95 g/mol
溶解性
DMSO : 10 mg/mL (23.81 mM; ultrasonic and warming and heat to 60°C)|Water : 2.5 mg/mL (5.95 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol