GlpBio

QL-IX-55

目录号: GC18032纯度: >98%同义词: 9-(6-氨基-3-吡啶基)-1-[4-氟-3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮
COASDSData Sheet
QL-IX-55 是一种选择性的 ATP 竞争性 mTORC1/2 抑制剂，对人 mTORC1/酵母 mTORC1/酵母 mTORC2 的 IC50 分别为 50/50/10-50 nM。
QL-IX-55
Cas No.: 1223002-54-7
规格价格库存数量操作
5mg¥2,804.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
1223002-54-7
同义词
9-(6-氨基-3-吡啶基)-1-[4-氟-3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮
化学名
9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
SMILES
O=C1C=CC2=CN=C3C=CC(C4=CN=C(N)C=C4)=CC3=C2N1C5=CC(C(F)(F)F)=C(F)C=C5
分子式
C24H14F4N4O
分子量
450.39 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol