Propargylcholine (bromide) is a choline analog containing a terminal propargyl group. Propargylcholine (bromide) can serve as a metabolic precursor for incorporation into various choline-containing phospholipids (such as phosphatidylcholine), enabling their high-sensitivity and high-resolution visualization. The alkyne group within the Propargylcholine (bromide) structure allows for efficient covalent linkage with azide-containing molecules via a copper-catalyzed azide-alkyne cycloaddition reaction. Propargylcholine (bromide) can be used to study the dynamic metabolic processes of intracellular choline phospholipids and serves as an efficient chemical reporter probe in the fields of click chemistry labeling and bioimaging[1-3].
References:
[1] Karen R. Bottenfield, Tara L. Moore, Farzad, Mortazavi, et al. Optimization of Propargylcholine to Label Newly Synthesized Myelin in the Rhesus Monkey Brain. FASEB J. 2020, 34(S1): 1-1.
[2] Acharya HP, Miyoshi K, Kobayashi Y. Mercury-free preparation and selective reactions of propargyl (and propargylic) Grignard reagents. Org Lett. 2007 Aug 30;9(18):3535-8.
[3] Wang W, Zhao J, Li T, et al. Enzalutamide-Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone-Sensitive Prostate Cancer. Adv Sci (Weinh). 2025 Nov;12(44):e10602.
Propargylcholine (bromide)是一种含有末端炔丙基的胆碱类似物，可作为代谢前体掺入多种含胆碱的磷脂（如磷脂酰胆碱）中，实现对其的高灵敏度和高分辨率可视化。Propargylcholine (bromide)结构中的炔基（Alkyne）能够通过铜催化的叠氮-炔环加成反应与含叠氮基的分子高效共价连接。Propargylcholine (bromide)可用于研究细胞内胆碱磷脂的动态代谢过程，并作为一种高效的化学报告探针应用于点击化学标记与生物成像领域[1-3]。