Gibberellic acid is a plant hormone belonging to the gibberellins, which are widely present in plants and can promote plant growth and development[1]. Gibberellic acid can also induce liver and kidney dysfunction in rats and generate oxidative stress.
The application of different levels of nitrogen alone and in combination with Gibberellic acid (60g/ha) and the urease inhibitor (NBPT) significantly increased the yield of corn[2]. Gibberellic acid (0.05µM) alleviates cadmium toxicity in rice by regulating NO accumulation and cell wall fixation capacity of cadmium[3]. Gibberellic acid (0 and 0.05μM; 14 days) mitigates nickel stress in soybean by cell wall fixation and regulating oxidative stress metabolism and glyoxalase system[4]. Gibberellic acid (100mg/L; 14 days)-induced generation of hydrogen sulfide alleviates boron toxicity in tomato (Solanum lycopersicum L.) plants[5]. Pre-treatment with Gibberellic acid (600μM; 1h) improved the viability of LPS-stimulated BV2 microglial cells[6].
In animal experiments, Gibberellic acid (5mg/kg; 10 days; i.g.) significantly reduced the expression of multiple inflammatory factors in the hippocampus of sepsis mice[6]. Gibberellic acid (55mg/kg; i.g.) induces dysfunction of liver and kidney and oxidative stress in male albino rats[7].
References:
[1] Huang YP, Chen IH, Kao YS, et al. The gibberellic acid derived from the plastidial MEP pathway is involved in the accumulation of Bamboo mosaic virus. New Phytol. 2022 Aug;235(4):1543-1557.
[2] Ullah I, Dawar K, Tariq M, et al. Gibberellic acid and urease inhibitor optimize nitrogen uptake and yield of maize at varying nitrogen levels under changing climate. Environ Sci Pollut Res Int. 2022 Jan;29(5):6568-6577.
[3] Liu YS, Tao Y, Yang XZ, et al. Gibberellic acid alleviates cadmium toxicity in rice by regulating NO accumulation and cell wall fixation capacity of cadmium. J Hazard Mater. 2022 Oct 5;439:129597.
[4] Bhat JA, Basit F, Alyemeni MN, et al. Gibberellic acid mitigates nickel stress in soybean by cell wall fixation and regulating oxidative stress metabolism and glyoxalase system. Plant Physiol Biochem. 2023 May;198:107678.
[5] Kaya C, Sarıoğlu A, Ashraf M, et al. Gibberellic acid-induced generation of hydrogen sulfide alleviates boron toxicity in tomato (Solanum lycopersicum L.) plants. Plant Physiol Biochem. 2020 Aug;153:53-63.
[6] Xu HJ, Lin YY, Yu JJ, et al. Gibberellic acid targeting ZBTB16 reduces NF-κB dependent inflammatory stress in sepsis-induced neuroinflammation. Eur J Pharmacol. 2024 Aug 5;976:176665.
[7] Soliman MM, Gaber A, Alsanie WF, et al. Gibberellic acid-induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti-inflammatory, and antiapoptotic activities. J Food Biochem. 2022 Feb;46(2):e14069.
Gibberellic acid是一种属于赤霉素类的植物激素，广泛存在于植物中，并且能够促进植物的生长和发育[1]。Gibberellic acid还会诱导大鼠肝肾功能损伤并产生氧化应激。
单独使用不同水平的氮肥以及与Gibberellic acid（60g/ha）和脲酶抑制剂（NBPT）联合使用，显著提高了玉米的产量[2]。Gibberellic acid（0.05µM）通过调节NO积累和镉的细胞壁固定能力，缓解了水稻中的镉毒性[3]。Gibberellic acid（0和0.05µM; 14天）通过细胞壁固定和调节氧化应激代谢及乙二醛酶系统来缓解大豆中的镍胁迫[4]。Gibberellic acid（100mg/L; 14天）诱导的硫化氢生成可缓解番茄（Solanum lycopersicum L.）植株的硼毒性[5]。预先用Gibberellic acid（600µM; 1小时）处理，可提高LPS刺激的BV2小胶质细胞的存活率[6]。
在动物体内实验中，Gibberellic acid（5mg/kg; 10天; 灌胃）显著降低了脓毒症小鼠海马体中多种炎症因子的表达[6]。Gibberellic acid（55mg/kg; 灌胃）在雄性白化大鼠中诱导了肝肾功能障碍和氧化应激[7]。