Monensin sodium salt is a polyether ionophore antibiotic that exhibits antibacterial activity against a variety of Gram-positive bacteria. Monensin sodium salt is used for the treatment and prevention of coccidiosis in poultry and other livestock [1]. Monensin sodium salt is an ionophore that mediates Na+/H+ exchange and is used as a tool to study ionophore mechanisms[2]. Additionally, Monensin sodium salt is an effective inhibitor of Wnt signaling[3]. Monensin sodium salt also has the potential to inhibit cancer development[4].
In vitro, treatment of human colorectal cancer cells RKO and HCT-116 with Monensin sodium salt (4μM) significantly inhibits cell proliferation, migration, and cell cycle progression, while inducing apoptosis and G1 arrest. Moreover, Monensin sodium salt can suppress the expression of IGF1R by increasing the expression of IGF1[5]. Monensin sodium salt (0.1–10μM) treatment of human peripheral blood eosinophils for 2 hours induces apoptosis-like cell death, with minimal effects on neutrophils[6].
In vivo, Monensin sodium salt (1mg/kg) was administered intraperitoneally to BALB/c mice sensitized with house dust mite (HDM) for 6 weeks. Monensin sodium salt significantly reduced the infiltration of eosinophils and lymphocytes into the airway lumen and decreased the lung tissue inflammation score[7]. Monensin sodium salt (10mg/kg) was administered intraperitoneally in a xenograft tumor model established with the pancreatic cancer cell line Panc-1. Monensin sodium salt significantly inhibited tumor growth, reduced tumor volume, and decreased the expression of proliferating cell nuclear antigen (PCNA) and epidermal growth factor receptor (EGFR) in the tumor tissues[8].
References:
[1] Rajendran V, Ilamathi HS, Dutt S, et al. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent. Curr Top Med Chem. 2018;18(22):1976-1986.
[2] Dias SADN, Divyasorubini S, Gamage KTJ, et al. Na+/K+ carrier ionophore antibiotics valinomycin and monensin enhance the antibacterial activity of fluoride. J Antibiot (Tokyo). 2023 Jul;76(7):425-429.
[3] Fu B, Fang L, Wang R, et al. Inhibition of Wnt/β-catenin signaling by monensin in cervical cancer. Korean J Physiol Pharmacol. 2024 Jan 1;28(1):21-30.
[4] Markowska A, Kaysiewicz J, Markowska J, et al. Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1549-1554.
[5] Zhou Y, Deng Y, Wang J, et al. Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 Dec;55(1):954-964.
[6] Vraila M, Asp E, Melo FR, et al. Monensin induces secretory granule-mediated cell death in eosinophils. J Allergy Clin Immunol. 2023 Nov;152(5):1312-1320.e3.
[7] Allam VSRR, Akula S, Waern I, et al. Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice. Inflammation. 2025 Apr;48(2):806-819.
[8] Wang X, Wu X, Zhang Z, et al. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep. 2018 Dec 17;8(1):17914.
Monensin sodium salt是一种聚醚类离子载体抗生素，对多种革兰氏阳性菌具有抗菌活性。Monensin sodium salt用于治疗和预防家禽及其他家畜的球虫病[1]。Monensin sodium salt是一种介导Na+/H+交换的离子载体，被用于研究离子载体机制的工具[2]。此外，Monensin sodium salt是一种有效的Wnt信号传导抑制剂[3]。Monensin sodium salt还具备抑制癌症发展的作用 [4]。
Monensin sodium salt是一种聚醚类离子载体抗生素，对多种革兰氏阳性菌具有抗菌活性。Monensin sodium salt用于治疗和预防家禽及其他家畜的球虫病[1]。Monensin sodium salt是一种介导Na+/H+交换的离子载体，被用于研究离子载体机制的工具[2]。此外，Monensin sodium salt是一种有效的Wnt信号传导抑制剂[3]。Monensin sodium salt还具备抑制癌症发展的作用 [4]。
在体外，Monensin sodium salt（4μM）处理人结直肠癌细胞RKO和HCT-116，Monensin sodium salt显著抑制细胞增殖、迁移以及细胞周期进程，并诱导细胞凋亡和G1期阻滞。此外，Monensin sodium salt还可通过增加IGF1的表达来抑制IGF1R的表达[5]。Monensin sodium salt（0.1–10μM）处理人外周血嗜酸性粒细胞2小时，可诱导细胞凋亡样死亡，而对中性粒细胞影响较小[6]。
在体内，Monensin sodium salt（1mg/kg）通过腹腔注射给药，用于处理经屋尘螨（HDM）致敏的BALB/c小鼠，持续6周。Monensin sodium salt显著减少了嗜酸性粒细胞和淋巴细胞向气道腔的浸润，降低了肺组织炎症评分[7]。Monensin sodium salt（10mg/kg）通过腹腔注射给药，用于处理胰腺癌细胞系Panc-1建立的裸鼠皮下移植瘤模型。Monensin sodium salt显著抑制了移植瘤的生长，降低了肿瘤体积，并减少了肿瘤组织中增殖细胞核抗原（PCNA）和表皮生长因子受体（EGFR）的表达[8]。