10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities.1,2,3,4 It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 ?M, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 ?M.1 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils.2 It is active against M. avium and M. tuberculosis (MICs = 25 and 50 ?g/ml, respectively).3 10-Gingerol (200 ?M) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.4
1.Dugasani, S., Pichika, M.R., Nadarajah, V.D., et al.Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaolJ. Ethnopharmacol.127(2)515-520(2010) 2.Ali, R.A., Gandhi, A.A., Dai, L., et al.Antineutrophil properties of natural gingerols in models of lupusJCI Insight6(3)e138385(2021) 3.Hiserodt, R.D., Franzblau, S.G., and Rosen, R.T.Isolation of 6-, 8-, and 10-gingerol from ginger rhizome by HPLC and preliminary evaluation of inhibition of Mycobacterium avium and Mycobacterium tuberculosisJ. Agric. Food Chem.46(7)2504-2508(1998) 4.Bernard, M.M., McConnery, J.R., and Hoskin, D.W.[10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cellsExp. Mol. Pathol.102(2)370-376(2017)