| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5mg | ¥1,890.00 | 现货 | 1 | |
| 10mg | ¥3,240.00 | 现货 | 1 |
ORG 41841 is a dual luteinizing hormone (LH) and thyroid-stimulating hormone (TSH) receptor agonist.1 It induces cAMP production in HEK293 cells expressing human LH or TSH receptors (EC50s = 0.3 and 6.5 ?M, respectively).
1.Moore, A., Jaeschke, H., Kleinau, G., et al.Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: Structure-activity relationships and selective binding patternsJ. Med. Chem.49(13)3888-3896(2006)
Kinase experiment: | Transfected cells are cultured for 48 h before incubation for 1 h in serum-free Dulbecco's modified Eagle's medium containing 1 mM 3-isobutyl-1-methylxanthine and bovine thyroid-stimulating hormone (TSH) (0 to 1.8 μM) or human LH (0.1 to 1000 ng) or Org41841 (0 to100 μM) in a humidified 5% CO2 incubator. Following aspiration of the medium, cells are lysed using lysis buffer 1 of the cAMP Biotrak Enzymeimmunoassay System. The cAMP content of the cell lysate is determined and data are analyzed[1]. |
References: [1]. Holger Jaschke, et al. A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor(LHCGR). J Biol Chem. 2006 Apr 14;281(15):9841-4. |
