N6-Ethyladenosine is an adenosine A1 and A3 receptor agonist.1 It binds selectively to rat adenosine A1 and human adenosine A3 receptors over rat adenosine A2A and A3 receptors (Kis = 4.9, 4.7, 8,900 and 1,050 nM, respectively, for the recombinant receptors in CHO cells). N6-Ethyladenosine completely inhibits forskolin-induced cAMP accumulation in CHO cells expressing the human recombinant adenosine A3 receptor when used at a concentration of 10 ?M.
1.Gao, Z.-G., Blaustein, J.B., Gross, A.S., et al.N6-Substituted adenosine derivatives: Selectivity, efficacy, and species differences at A3 adenosine receptorsBiochem. Pharmacol.65(10)1675-1684(2003)