Myricetin is a natural flavonoid commonly found in plants, possessing antioxidant, anti-inflammatory, and anti-tumor activities, and acts as a novel inhibitor of mitogen-activated protein kinase kinase (MEK1) and neoplastic transformation in JB6 P+ mouse epidermal cells[1,2]. Myricetin is commonly used in the treatment and research of various types of tumors, diabetes, Alzheimer's disease, and inflammatory diseases[3].
In vitro, pre-incubation of human colon cancer Hct116 cells with myricetin (50μM) for 4h, followed by induction of oxidative stress with 500μM H2O2 for 1h, significantly reduced intracellular reactive oxygen species (ROS) accumulation to 46.1% ± 9.1% of the control group[4]. Pre-treatment of JB6 P+ cells with myricetin (2.5-20μM) for 1h, followed by UVB irradiation (0.05 J/cm2), inhibited UVB-induced cyclooxygenase-2 (COX-2) protein expression and promoter activity in a dose-dependent manner[5].
In vivo, oral administration of myricetin (50mg/kg/day) to ICR mice for 3 consecutive weeks significantly enhanced their aerobic capacity and improved motor coordination[6]. Intravenous administration of myricetin (1mg/kg/time; 3 times daily) to high-fructose diet-induced insulin-resistant Wistar rats for 14 days significantly reduced elevated plasma blood glucose and triglyceride levels[7]. Oral gavage of myricetin (150mg/kg/day) to high-fat diet (HFD)-induced obese C57BL/6 mice for 10 weeks significantly reduced body weight and decreased serum glucose and triglyceride levels[8].
References:
[1] IMRAN M, SAEED F, HUSSAIN G, et al. Myricetin: A comprehensive review on its biological potentials[J]. Food science & nutrition, 2021, 9(10): 5854-5868.
[2] LEE K W, KANG N J, ROGOZIN E A, et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1[J]. Carcinogenesis, 2007, 28(9): 1918-1927.
[3] SONG X, TAN L, WANG M, et al. Myricetin: A review of the most recent research[J]. Biomedicine & Pharmacotherapy, 2021, 134: 111017.
[4] BüCHTER C, ACKERMANN D, HAVERMANN S, et al. Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16[J]. International journal of molecular sciences, 2013, 14(6): 11895-11914.
[5] JUNG S K, LEE K W, BYUN S, et al. Myricetin suppresses UVB-induced skin cancer by targeting Fyn[J]. Cancer research, 2008, 68(14): 6021-6029.
[6] JUNG H Y, LEE D, RYU H G, et al. Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α[J]. Scientific reports, 2017, 7: 6237.
[7] LIU I M, TZENG T F, LIOU S S, et al. Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats[J]. Life sciences, 2007, 81(21-22): 1479-1488.
[8] SU H, FENG L, ZHENG X, et al. Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice[J]. Journal of Zhejiang University-Science B, 2016, 17(6): 437-446.
Myricetin是一种常见于植物且具有抗氧化、抗炎和抗肿瘤活性的天然黄酮类化合物，是丝裂原活化蛋白激酶激酶（MEK1）和 JB6 P+小鼠表皮细胞转化的新型抑制剂[1,2]。Myricetin通常用于不同类型肿瘤、糖尿病、阿尔兹海默症和炎症性疾病等的治疗和研究[3]。
在体外，myricetin（50μM）预孵育人结肠癌Hct116细胞4h，后施加500μM H2O2诱导氧化应激1h，显著降低了细胞内活性氧（ROS）积累至对照组的46.1% ± 9.1%[4]。Myricetin（2.5-20μM）预处理JB6 P+细胞1h，后照射UVB（0.05 J/cm2），以剂量依赖性方式抑制了UVB诱导的环氧化酶-2（COX-2）蛋白表达和启动子活性[5]。
在体内，myricetin（50mg/kg/day）通过口服给药ICR小鼠连续3周，显著增强了小鼠的有氧能力并改善了运动协调性[6]。Myricetin（1mg/kg/time; 3 times daily）通过静脉注射处理高果糖饮食诱导的胰岛素抵抗Wistar大鼠14天，可显著降低大鼠血浆中过高的血糖和甘油三酯水平[7]。Myricetin（150mg/kg/day）通过口服灌胃给药高脂饮食（HFD）诱导的肥胖C57BL/6小鼠10周，显著减轻了小鼠的体重并降低了血清中葡萄糖和甘油三酯的水平[8]。