MSG 606

MSG-606 has potent antagonist activity and receptor selectivity for the human melanocortin 1 receptor (hMC1R) (IC50 = 17 nM) ^[1].

MSG-606 is an excellent probe for targeting specifically melanoma cells for skin cancer diagnosis. MSG-606 act as antagonist toward the melanoma cells. Binding and cAMP Activities of MSG-606 against Human Melanoma Cells (A375) with IC50 of 96 nM ^[1].

MSG-606 (1 nmol/μl, 6 μl) abolished the neuroprotective effects of the BMS-470539/MC1R system, in a subarachnoid hemorrhage (SAH) model ^[2].

References:
[1]:Cai M, Stankova M, Muthu D, et al. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells[J]. Biochemistry, 2013, 52(4): 752-764.
[2]:Xu, W., Mo, J., Ocak, U. et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics 17, 294-308 (2020). https://doi.org/10.1007/s13311-019-00772-x

MSG-606 对人黑皮质素 1 受体 (hMC1R) 具有强效拮抗活性和受体选择性（IC50 = 17 nM）^[1]。

MSG-606 是一种出色的探针,可专门针对黑色素瘤细胞进行皮肤癌诊断。 MSG-606 作为黑色素瘤细胞的拮抗剂。 MSG-606 对人黑色素瘤细胞 (A375) 的结合和 cAMP 活性,IC50 为 96 nM ^[1]。

MSG-606（1 nmol/μl,6 μl）在蛛网膜下腔出血 (SAH) 模型中消除了 BMS-470539/MC1R 系统的神经保护作用^[2]。