GlpBio

MK-447

目录号: GC31966纯度: >98%
COASDSData Sheet
MK-447是一种自由基清除剂，同时为非甾体类抗炎剂，能够增强PGH2等其他前列腺素(prostaglandin)的形成。
MK-447
Cas No.: 58456-91-0
规格价格库存数量操作
1mg¥5,025.00现货
1
5mg¥8,041.00现货
1
10mg¥12,870.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.

MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG2 and also enhances the formation of the endoperoxide, PGH2, and other prostaglandins[1]. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta[2].

MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1].

[1]. Shriver DA, et al. The gastric antisecretory and antiulcer activity of MK-447, an enhancer of prostaglandin synthesis. Life Sci. 1980 Dec 22-29;27(25-26):2483-7. [2]. Harada Y, et al. Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447. Jpn J Pharmacol. 1981 Oct;31(5):845-8.

实验参考方法 Experimental Reference Method

Animal experiment:

Male Charles River CD rats weighing 140 and 200 g are fasted overnight with water ad lib. The rats are pretreated orally with compound (MK-447) or buffered glycol vehicle in a dosage volume of 1.0 mL/kg one hour before challenge with the necrotizing agents. The necrotizing agents [acetylsalicyclic acid at 40 suspended in 0.5% methylcellulose (1500 cps) or 37.5% ethanol] are administered p.o. in a dose volume of 0.1 mL/100 g body weight or 1 mL/rat, respectively. Rats are killed with CO2 one hour after acetylsalicylic acid or ethanol, the stomach removed, inflated with water, and opened ture. The presence of mucosal bleeding is noted and the mucosa is wiped off[1].

References:

[1]. Shriver DA, et al. The gastric antisecretory and antiulcer activity of MK-447, an enhancer of prostaglandin synthesis. Life Sci. 1980 Dec 22-29;27(25-26):2483-7.
[2]. Harada Y, et al. Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447. Jpn J Pharmacol. 1981 Oct;31(5):845-8.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
58456-91-0
SMILES
OC1=C(I)C=C(C(C)(C)C)C=C1CN
分子式
C11H16INO
分子量
305.16 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol