Harmaline

Harmaline is a psychoactive indole found naturally in certain plants. Its stimulating activities are achieved, in part, through inhibition of monoamine oxidases, thus increasing the levels of monoamine neurotransmitters (e.g., at 7-70 μM/kg in rats). Harmaline (30 mg/kg) induces tremor in mice through the N-methyl-D-aspartate (NMDA) receptor, at which harmaline may act as an inverse agonist. This compound has also been identified as an adulterant in herbal mixtures containing synthetic cannabinoids and described as contributing to poisoning when combined with a hallucinogenic tryptamine. This product is intended for forensic or research purposes.