GlpBio

GSK2018682

目录号: GC31863纯度: >98.00%
An S1P1 and S1P5 receptor agonist
GSK2018682
Cas No.: 1034688-30-6
规格价格库存数量操作
1mg¥234.00现货
1
5mg¥486.00现货
1
10mg¥810.00现货
1
50mg¥2,880.00现货
1
10mM (in 1mL DMSO)¥535.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

GSK2018682 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) and S1P5.1 It is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 receptors. GSK2018682 is efficacious in a mouse model of experimental autoimmune encephalomyelitis (EAE).

1.Xu, J., Gray, F., Henderson, A., et al.Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteersClin. Pharmacol. Drug Dev.3(3)170-178(2014)

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1034688-30-6
SMILES
O=C(O)CCCN1C=CC2=C1C=CC=C2C3=NOC(C4=CC(Cl)=C(OC(C)C)N=C4)=N3
分子式
C22H21ClN4O4
分子量
440.88 g/mol
溶解性
DMS : ≥ 125 mg/mL (283.52 mM);Water : < 0.1 mg/mL (insoluble)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol