GOT1 inhibitor-1 is a small-molecule selective inhibitor of GOT1 (glutamic oxaloacetic transaminase 1) with an IC50 of 8.2 μM. GOT1 inhibitor-1 has potential application value in cancer therapy[1]. GOT1 is a key protein in energy metabolism and the balance of reactive oxygen species (ROS)[2]. GOT1 inhibitor-1, which is N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide, can reduce the viability of cancer cells by inhibiting the activity of GOT1 and disrupting the metabolic pathway balance[1].
References:
[1] Anglin J, Zavareh RB, Sander PN, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678.
[2] Peng H, Dou H, He S, et al. The role of GOT1 in cancer metabolism. Front Oncol. 2024 Dec 24;14:1519046.
GOT1 inhibitor-1是一种小分子的GOT1（谷氨酸草酰乙酸转氨酶1）选择性抑制剂，IC50为8.2uM，GOT1 inhibitor-1在癌症治疗方面具有潜在的应用价值[1]。GOT1能量代谢和活性氧（ROS）平衡的关键蛋白[2]，GOT1 inhibitor-1是N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺，能够引起通过抑制GOT1的活性，破坏代谢途径的平衡降低癌细胞的生存能力[1]。