Phosphatidylglycerols (sodium salt) is a phospholipid that is ubiquitous in almost all living organisms, with molecular structure features a negatively charged glycerol head group, which exists stably in the form of a sodium salt[1]. Phosphatidylglycerols can inhibit the activation of Toll-like receptors (TLR) in the innate immune system of the lungs by microbial components, resulting in a reduction in the production of inflammatory mediators, and alleviation of lung inflammation and damage[2]. Phosphatidylglycerols have been widely used to enhance mitochondrial function and promote skin wound healing[3].
In vitro, Phosphatidylglycerols (50μM twice at 0 and 12 hours) significantly rescued the total oxygen consumption rates (OCR) and mitochondrial activity inhibited by Kdo2-Lipid A (KLA) in RAW264.7 cells[4].
References:
[1] Wada H, Murata N. The essential role of phosphatidylglycerol in photosynthesis[J]. Photosynthesis research, 2007, 92(2): 205-215.
[2] Bollag W B, Gonzales J N. Phosphatidylglycerol and surfactant: A potential treatment for COVID-19?[J]. Medical Hypotheses, 2020, 144: 110277.
[3] Luo Y, Vivaldi Marrero E, Choudhary V, et al. Phosphatidylglycerol to treat chronic skin wounds in diabetes[J]. Pharmaceutics, 2023, 15(5): 1497.
[4] Chen W W, Chao Y J, Chang W H, et al. Phosphatidylglycerol incorporates into cardiolipin to improve mitochondrial activity and inhibits inflammation[J]. Scientific reports, 2018, 8(1): 4919.
Phosphatidylglycerols (sodium salt)是一种普遍存在于几乎所有生物体中的磷脂，分子结构特征为带负电荷的甘油头部基团，以钠盐形式稳定存在[1]。Phosphatidylglycerols可通过抑制微生物成分对肺先天免疫系统中Toll样受体（TLR）的激活，减少炎症介质产生，减轻肺部炎症和损伤[2]。Phosphatidylglycerols被广泛应用于增强线粒体功能和促进皮肤伤口愈合[3]。
在体外，Phosphatidylglycerols（50μM的剂量分别在0和12小时两次处理）能显著恢复Kdo2-Lipid A (KLA)抑制的RAW264.7细胞总耗氧率（OCR）和线粒体活性[4]。