GLP-1 (1-37) (human, rat, mouse, bovine) (trifluoroacetate salt) is a full-length precursor form of glucagon-like peptide-1 secreted by the intestine [1]. GLP-1 (1-37) itself has low activity and does not directly activate the GLP-1 receptor. It is mainly used to study the processing mechanism of GLP-1, structure-function analysis, cross-species comparison, and the development of new GLP-1 receptor agonists [2-3].
In CD4-positive lymphocytes, GLP-1 (1-37) (1nM; 30min) reduces chemokine-induced migration of CD4-positive lymphocytes [4].
In C57BL/6 pregnant mice, GLP-1 (1-37) (10nM; ip; 8d) converts developing intestinal epithelial cells into insulin-producing cells in vivo [5].
References:
[1]. Fehmann HC, Göke R, Göke B. Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocrine reviews. 1995 Jun 1; 16(3): 390-410.
[2]. KAWAI K, SUZUKI S, OHASHI S, et al. Comparison of the effects of glucagon-like peptide-1-(1-37) and-(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreases. Endocrinology. 1989 Apr 1; 124(4): 1768-1773.
[3]. Vahl TP, Paty BW, Fuller BD, et al. Effects of GLP-1-(7–36) NH2, GLP-1-(7–37), and GLP-1-(9–36) NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. The Journal of Clinical Endocrinology & Metabolism. 2003 Apr 1; 88(4): 1772-1779.
[4]. Marx N, Burgmaier M, Heinz P, et al. Glucagon-like peptide-1 (1-37) inhibits chemokine-induced migration of human CD4-positive lymphocytes. Cellular and molecular life sciences. 2010 Oct; 67: 3549-3555.
[5]. Suzuki A, Nakauchi H, Taniguchi H. Glucagon-like peptide 1 (1–37) converts intestinal epithelial cells into insulin-producing cells. Proceedings of the National Academy of Sciences. 2003 Apr 29; 100(9): 5034-5039.
GLP-1 (1-37) (human, rat, mouse, bovine) (trifluoroacetate salt)是由肠道分泌的胰高血糖素样肽-1的全长前体 [1]。GLP-1 (1-37)本身活性较低，不直接激活GLP-1受体。主要用于研究GLP-1的加工机制、结构-功能分析、跨物种比较以及新型GLP-1受体激动剂的开发 [2-3]。
在CD4阳性淋巴细胞中，GLP-1 (1-37)（1nM；30分钟）可降低趋化因子诱导的CD4阳性淋巴细胞迁移 [4]。
在C57BL/6怀孕小鼠中，GLP-1 (1-37)（10nM；ip；8d）可将发育中的肠上皮细胞转化为体内产生胰岛素的细胞 [5]。