N-3-Oxo-octanoyl-L-homoserine lactone is a quorum-sensing signaling molecule belonging to the N-acylhomoserine lactone (AHL) family, which is often used to study bacterial communication and biofilm formation [1]. N-3-Oxo-octanoyl-L-homoserine lactone protects Arabidopsis against a hemibiotrophic pathogen by priming the defense response and that N-3-Oxo-octanoyl-L-homoserine lactone-mediated priming requires the SA signaling pathway [2]. N-3-Oxo-octanoyl-L-homoserine lactone pretreatment (10μM; for 2 days), upon pathogenic bacterium Pseudomonas syringae pv. tomato DC3000 challenge, Arabidopsis showed increased activities of defense-related enzymes including peroxidase, catalase, phenylalanine ammonialyase, and superoxide dismutase[2]. N-3-Oxo-octanoyl-L-homoserine lactone has been widely used for plant protection and as an internal reference for the development of new detection and analytical methods[3].
References:
[1] Aybey A, Sinan S, Askun T. Signal interference effect of human paraoxonase 1 using as substrates N-hexanoyl-L-homoserine lactone and N-3-oxo-octanoyl-L-homoserine lactone on growth of pathogenic bacteria[J]. Applied Biochemistry and Microbiology, 2015, 51(6): 726-731.
[2] Liu F, Zhao Q, Jia Z, et al. N-3-oxo-octanoyl-homoserine lactone-mediated priming of resistance to Pseudomonas syringae requires the salicylic acid signaling pathway in Arabidopsis thaliana[J]. BMC plant biology, 2020, 20(1): 38.
[3] Gosset-Erard C, Han G, Kyrko D, et al. Structural characterization of N-acyl-homoserine lactones from bacterial quorum sensing using LC–MS/MS analyses after Paternò-Büchi derivatization in solution[J]. Analytical and Bioanalytical Chemistry, 2024, 416(25): 5431-5443.
N-3-Oxo-octanoyl-L-homoserine lactone是一种属于N-酰基高丝氨酸内酯（AHL）家族的群体感应信号分子，常用于研究细菌通讯和生物膜形成[1]。N-3-Oxo-octanoyl-L-homoserine lactone通过激活水杨酸信号通路来启动防御反应，从而保护拟南芥免受半活体营养型病原体的侵害[2]。当用10μM浓度的N-3-Oxo-octanoyl-L-homoserine lactone预处理2天后，拟南芥在受到病原菌Pseudomonas syringae pv. tomato DC3000侵染时，过氧化物酶、过氧化氢酶、苯丙氨酸解氨酶和超氧化物歧化酶等防御相关酶的活性显著提高[2]。N-3-Oxo-octanoyl-L-homoserine lactone已被广泛应用于植物保护领域，并作为开发新型检测和分析方法的内参标准[3]。