Gitogenin is a sapogenin that has been found in T. foenum-graecum and has enzyme inhibitory and hormone-releasing activities.1,2 It is an inhibitor of UDP-glucuronosyltransferase (UGT) isoform UGT1A4 (IC50 = 0.69 ?M).1 Gitogenin (20 ?g/ml) stimulates the release of growth hormone in primary rat pituitary cells.2
1.Xu, M., Dong, P., Tian, X., et al.Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for predictionPharmacol. Res.110139-150(2016) 2.Shim, S.H., Lee, E.J., Kim, J.S., et al.Rat growth-hormone release stimulators from fenugreek seedsChem. Biodivers.5(9)1753-1761(2008)
















