Mycophenolic acid D3 is a deuterium-labeled Mycophenolic acid, which is an immunosuppressant drug inhibiting the inosine-monophosphate dehydrogenase [1]. Mycophenolic acid D3 is widely used as an internal standard to develop a new type of liquid chromatography tandem mass spectrometry for quantitative analysis of Mycophenolic acid as well as the two additional metabolites, 7-O-mycophenolic acid glucuronide (MPAG), and mycophenolic acid acyl-glucuronide (AcMPAG) in plasma and serum[2].
References:
[1] Merrigan S D, Kish-Trier E, Seegmiller J C, et al. LC–MS/MS method for quantitation of mycophenolic acid, mycophenolic acid acyl-glucuronide, and 7-O-mycophenolic acid glucuronide in serum[J]. Clinical Mass Spectrometry, 2017, 3: 41-48.
[2] Garg U, Munar A, Frazee C. Quantitation of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Serum or Plasma by LC‐MS/MS[J]. Current Protocols, 2023, 3(4): e730.
Mycophenolic acid D3是氘代标记的Mycophenolic acid，是一种抑制肌苷-磷酸脱氢酶的免疫抑制剂[1]。Mycophenolic acid D3被广泛用作内标，以开发新型液相色谱-串联质谱法，用于定量分析血浆和血清中的Mycophenolic acid及其两种额外代谢物：7-O-mycophenolic acid glucuronide (MPAG)和mycophenolic acid acyl-glucuronide (AcMPAG) [2]。