GlpBio

Microcystin-LR

目录号: GC36607纯度: >95.00%同义词: 微囊藻毒素(LR亚型),Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa)

A potent protein phosphatase inhibitor

Microcystin-LR
Cas No.: 101043-37-2
规格价格库存数量操作
50 µg(0.5 mM * 100 µL in Ethanol)¥1,935.00现货
1
100 µg(0.5 mM * 200 µL in Ethanol)¥3,285.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1 They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

1.Rinehart, K.L., Harada, K.-i., Namikoshi, M., et al.Nodularin, microcystin, and the configuration of AddaJ. Am. Chem. Soc.110(25)8557-8558(1988) 2.Honkanen, R.E., Zwiller, J., Moore, R.E., et al.Characterization of microcystin-LR, a potent inhibitor of Type 1 and Type 2A protein phosphatasesJ. Biol. Chem.265(32)19401-19404(1990)

产品文档 Product Documents

Purity:>95.00%Appearance:A solution in ethanol

化学性质Chemical Properties

CAS 号
101043-37-2
同义词
微囊藻毒素(LR亚型),Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa)
化学名
cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
SMILES
CC(/C=C/[C@@H]([C@@H](C(N[C@H](CCC(N(C(C(N[C@@H]1C)=O)=C)C)=O)C(O)=O)=O)C)NC([C@@H](NC([C@H]([C@@H](NC([C@](NC1=O)([H])CC(C)C)=O)C(O)=O)C)=O)CCCNC(N)=N)=O)=C\[C@H](C)[C@@H](OC)CC2=CC=CC=C2
分子式
C49H74N10O12
分子量
995.2 g/mol
溶解性
DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Methanol: 10 mg/ml
保存条件
Store at -20°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol