Ganoderic acid G is a triterpenoid that has been found in G. lucidum and has anticancer and anti-inflammatory activities.1,2 It inhibits the proliferation of Meth A sarcoma cells (IC50 = 6.8 ?g/ml).1 Ganoderic acid G inhibits the production of nitric oxide (NO) in LPS-induced BV-2 microglial cells (IC50 = 5.77 ?M).2
1.Min, B.S., Gao, J.J., Nakamura, N., et al.Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cellsChem. Pharm. Bull. (Tokyo)48(7)1026-1033(2000) 2.Yang, J., Ting, X., Zou, L.-H., et al.Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microgliaBioorg. Med. Chem. Lett.26(15)3556-3561(2018)