Asoprisnil is a selective progesterone receptor modulator (SPRM).1 It selectively binds to the progesterone receptor over the glucocorticoid receptor. Asoprinil inhibits the proliferation of vaginal epithelium and induces mucification of the vaginal epithelium in guinea pigs. It also inhibits ovulation in guinea pigs when administered at doses greater than 1 mg/kg.2
1.Schubert, G., Elger, W., Kaufmann, G., et al.Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11β-benzaldoxime substituted selective progesterone receptor modulators (SPRMs)Semin. Reprod. Med.23(1)58-73(2005) 2.DeManno, D., Elger, W., Garg, R., et al.Asoprisnil (J867): A selective progesterone receptor modulator for gynecological therapySteroids68(10-13)1019-1032(2003)