GlpBio

Flucloxacillin sodium

目录号: GC33709纯度: >95.00%同义词: 氟氯西林钠
A β-lactam antibiotic
Flucloxacillin sodium
Cas No.: 1847-24-1
规格价格库存数量操作
100mg¥210.00现货
1
500mg¥630.00现货
1
10mM (in 1mL DMSO)¥231.00现货
1
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文献被引

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产品描述 Description

Flucloxacillin is a β-lactam antibiotic.1 It is active against clinical isolates of S. aureus (MICs = 0.12-0.25 mg/L). Flucloxacillin (42.3 mg/kg every six hours) decreases vegetation titers in a rat model of aortic valve endocarditis induced by S. aureus. Formulations containing flucloxacillin have been used in the treatment of bacterial infections.

1.Entenza, J.M., Vouillamoz, J., Glauser, M.P., et al.Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureusAntimicrob. Agents Chemother.41(8)1662-1667(1997)

实验参考方法 Experimental Reference Method

Animal experiment:

Rats: On the day of the experiment the animal is given an intravenous bolus injection of 200 mg/kg as pure free acid sodium flucloxacillin (dose volume: 1 mL sterile water per kg) and then return to the metabolism cage. Urine is collected directly into individual CO2 cooled containers for a period of 24 h before dosing and then at frequent intervals after dosing[3].

References:

[1]. Paton DM, et al. Bioavailability and half-life of two preparations of flucloxacillin. N Z Med J. 1982 Nov 10;95(719):766-8.
[2]. Williams J, et al.Sweat tests and flucloxacillin. Arch Dis Child. 1988 Jul;63(7):847-8.
[3]. Everett JR, et al. 19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine. J Pharm Pharmacol. 1985 Dec;37(12):869-73.

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

CAS 号
1847-24-1
同义词
氟氯西林钠
SMILES
[O-]C([C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C(C(C(F)=CC=C3)=C3Cl)=NO4)=C4C)=O)([H])SC1(C)C)=O.[Na+]
分子式
C19H16ClFN3NaO5S
分子量
475.85 g/mol
溶解性
Water : ≥ 100 mg/mL (210.15 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol