GlpBio

Progesterone Receptor

Progesterone Receptor(孕激素受体)

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor 相关产品(35)

  • GC10017 structure
    GC10017Gestodene
    CAS: 60282-87-3
    纯度: >99.50%

    A progestin

  • GC10215 structure
    GC10215Norethindrone
    CAS: 68-22-4
    纯度: >99.50%

    A synthetic progestin

  • GC11144 structure
    GC11144Chlormadinone acetate
    CAS: 302-22-7
    纯度: >98.00%

    A synthetic progestin

  • GC11637 structure
    GC11637Mifepristone
    CAS: 84371-65-3
    纯度: >98.50% / >98.00%

    Mifepristone (RU486）是一种口服有效的孕酮（PR）受体和糖皮质激素受体（GR）拮抗剂，用作堕胎药物，体外实验中IC 50 值分别为0.2nM和2.6nM。

  • GC11677 structure
    GC11677Ulipristal acetate
    CAS: 126784-99-4
    纯度: >99.50%

    A selective progesterone receptor modulator

  • GC11688 structure
    GC11688Megestrol Acetate
    CAS: 595-33-5
    纯度: >99.50%

    A synthetic progestogen

  • GC11964 structure
    GC11964Desogestrel
    CAS: 54024-22-5
    纯度: >99.50%

    A synthetic progestogen

  • GC12000 structure
    GC12000Ethynodiol diacetate
    CAS: 297-76-7
    纯度: >99.00%

    A synthetic progestogen

  • GC12379 structure
    GC12379Drospirenone
    CAS: 67392-87-4
    纯度: >98.00%

    A synthetic progestogen

  • GC12408 structure
    GC12408Progesterone
    CAS: 57-83-0
    纯度: >98.00%

    An endogenous hormone and hormone precursor

  • GC12974 structure
    GC12974Medroxyprogesterone acetate
    CAS: 71-58-9
    纯度: >99.50%

    Medroxyprogesterone acetate（MPA）是一种人工合成的孕激素。

  • GC13297 structure
    GC13297Altrenogest
    CAS: 850-52-2
    纯度: >99.50%

    A synthetic progestin

  • GC15409 structure
    GC15409Dydrogesterone
    CAS: 152-62-5
    纯度: >98.00%

    A synthetic progestogen

  • GC15578 structure
    GC15578Dienogest
    CAS: 65928-58-7
    纯度: >98.00%

    A synthetic progestin and PR agonist

  • GC16847 structure
    GC16847Tanaproget
    CAS: 304853-42-7
    纯度: >99.50%

    Tanaproget (NSP-989) 是一种新型非甾体孕酮受体激动剂，与参考甾体孕激素相比，它可以以更高的相对亲和力与来自各种物种的 PR 结合。

  • GC17200 structure
    GC17200Nestoron
    CAS: 7759-35-5
    纯度: >99.50%

    A synthetic progestin

  • GC17305 structure
    GC17305Ulipristal
    CAS: 159811-51-5
    纯度: >98.00%

    A selective progesterone receptor modulator

  • GC34200 structure
    GC34200Gestonorone Capronate
    CAS: 1253-28-7

    GestonoroneCapronate是治疗良性前列腺肥大和子宫内膜癌的孕激素。

  • GC35408 structure
    GC35408Asoprisnil
    CAS: 199396-76-4
    纯度: >98.00%

    A selective progesterone receptor modulator

  • GC36755 structure
    GC36755Nomegestrol acetate
    CAS: 58652-20-3
    纯度: >98.50%

    Nomegestrol Acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.

  • GC36759 structure
    GC36759Norethindrone acetate
    CAS: 51-98-9
    纯度: >99.00%

    Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.

  • GC38648 structure
    GC38648Cridanimod
    CAS: 38609-97-1
    纯度: >99.50%

    An inducer of type I interferon production

  • GC39654 structure
    GC39654Norethisterone enanthate
    CAS: 3836-23-5
    纯度: >98.00%

    Norethisterone Enanthate (Norethindrone Enanthate) is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women.

  • GC41153 structure
    GC41153Tibolone
    CAS: 5630-53-5
    纯度: >98.00%

    Tibolone是一种合成类固醇，具有弱雌激素、孕激素及雄激素活性。